Secondary somatosensory cortex evoked responses and 6-year neurodevelopmental outcome in extremely preterm children

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http://hdl.handle.net/10138/333298

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Lönnberg , P , Pihko , E , Lauronen , L , Nurminen , J , Andersson , S , Metsäranta , M , Lano , A & Nevalainen , P 2021 , ' Secondary somatosensory cortex evoked responses and 6-year neurodevelopmental outcome in extremely preterm children ' , Clinical Neurophysiology , vol. 132 , no. 7 , pp. 1572-1583 . https://doi.org/10.1016/j.clinph.2021.04.005

Title: Secondary somatosensory cortex evoked responses and 6-year neurodevelopmental outcome in extremely preterm children
Author: Lönnberg, Piia; Pihko, Elina; Lauronen, Leena; Nurminen, Jussi; Andersson, Sture; Metsäranta, Marjo; Lano, Aulikki; Nevalainen, Päivi
Contributor: University of Helsinki, HUS Children and Adolescents
University of Helsinki, HUS Medical Imaging Center
University of Helsinki, HUS Medical Imaging Center
University of Helsinki, HUS Medical Imaging Center
University of Helsinki, Clinicum
University of Helsinki, HUS Children and Adolescents
University of Helsinki, HUS Medical Imaging Center
University of Helsinki, Staff Services
Date: 2021-07
Language: eng
Number of pages: 12
Belongs to series: Clinical Neurophysiology
ISSN: 1388-2457
URI: http://hdl.handle.net/10138/333298
Abstract: Objective: We assessed in extremely preterm born (EPB) children whether secondary somatosensory cor-tex (SII) responses recorded with magnetoencephalography (MEG) at term-equivalent age (TEA) correlate with neurodevelopmental outcome at age 6 years. Secondly, we assessed whether SII responses differ between 6-year-old EPB and term-born (TB) children. Methods: 39 EPB children underwent MEG with tactile stimulation at TEA. At age 6 years, 32 EPB and 26 TB children underwent MEG including a sensorimotor task requiring attention and motor inhibition. SII responses to tactile stimulation were modeled with equivalent current dipoles. Neurological outcome, motor competence, and general cognitive ability were prospectively evaluated at age 6 years. Results: Unilaterally absent SII response at TEA was associated with abnormal motor competence in 6-year-old EPB children (p = 0.03). At age 6 years, SII responses were bilaterally detectable in most EPB (88%) and TB (92%) children (group comparison, p = 0.69). Motor inhibition was associated with decreased SII peak latencies in TB children, but EPB children lacked this effect (p = 0.02). Conclusions: Unilateral absence of an SII response at TEA predicted poorer motor outcome in EPB children. Significance: Neurophysiological methods may provide new means for outcome prognostication in EPB children. (c) 2021 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Subject: Magnetoencephalography
Secondary somatosensory cortex
Child
Preterm
Outcome
Motor inhibition
CORTICAL ACTIVITIES
MAGNETIC-FIELDS
SII CORTICES
ATTENTION
HUMANS
MEG
MAGNETOENCEPHALOGRAPHY
STIMULATION
INTERFERENCE
ORGANIZATION
3112 Neurosciences
3124 Neurology and psychiatry
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