Neurocognitive impairment, employment, and social status in radiotherapy-treated adult survivors of childhood brain tumors

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Remes , T M , Hoven , E , Ritari , N , Pohjasniemi , H , Puosi , R , Arikoski , P M , Arola , M O , Lähteenmäki , P M , Lönnqvist , T R I , Ojaniemi , M K , Riikonen , V P , Sirkiä , K H , Winqvist , S , Rantala , H M J , Harila , M & Harila-Saari , A H 2021 , ' Neurocognitive impairment, employment, and social status in radiotherapy-treated adult survivors of childhood brain tumors ' , Neuro-Oncology practice , vol. 8 , no. 3 , pp. 266-277 . https://doi.org/10.1093/nop/npab004

Title: Neurocognitive impairment, employment, and social status in radiotherapy-treated adult survivors of childhood brain tumors
Author: Remes, Tiina M.; Hoven, Emma; Ritari, Niina; Pohjasniemi, Heli; Puosi, Riina; Arikoski, Pekka M.; Arola, Mikko O.; Lähteenmäki, Päivi M.; Lönnqvist, Tuula R. I.; Ojaniemi, Marja K.; Riikonen, V. Pekka; Sirkiä, Kirsti H.; Winqvist, Satu; Rantala, Heikki M. J.; Harila, Marika; Harila-Saari, Arja H.
Contributor: University of Helsinki, HUS Children and Adolescents
University of Helsinki, Children's Hospital
University of Helsinki, HUS Children and Adolescents
University of Helsinki, HUS Children and Adolescents
University of Helsinki, HUS Children and Adolescents
Date: 2021-06
Language: eng
Number of pages: 12
Belongs to series: Neuro-Oncology practice
ISSN: 2054-2577
URI: http://hdl.handle.net/10138/333359
Abstract: Background. Little is known of the cognitive functions, employment, and social status in adult survivors of childhood brain tumor (BT). We aimed to determine the long-term neurocognitive profile of radiotherapy-treated adult survivors of childhood BT and the relationship between cognitive functions and employment and social status. Methods. Neurocognitive profiles of survivors were assessed in a Finnish national cohort of 71 radiotherapy-treated survivors of childhood BT (median follow-up time: 21 years [range: 5-33 years]) using a cross-sectional design. Neurocognitive outcomes were compared to control (n = 45) and normative values. Tumor- and treatment-related data were collected from the patient files. Information on employment and social status was gathered. Results. Survivors' (median age: 27 years [range: 16-43 years]) median verbal and performance intelligence quotient (IQ) was 90 (range: 49-121) and 87 (range: 43-119), respectively. The cognitive domains with the greatest impairment were executive functions (median z score, 3.5 SD [range: -25.0 to 1.3 SD]), and processing speed and attention (median z score, -2.5 SD [range: -24.9 to 0.5 SD]). Executive functions were associated with employment, educational level, living independently, having an intimate relationship, and having a driving license. Processing speed and attention were related to educational level, living independently, having an intimate relationship, and having a driving license. Performance IQ was associated with educational level and employment status. Working memory was associated with educational level and living independently. Conclusions. Radiotherapy-treated adult survivors of childhood BT experience significant neurocognitive impairment, which is associated with difficulties related to employment and social status.
Subject: brain tumor
employment
neurocognitive impairment
radiation
social status
WORKING-MEMORY
COGNITIVE FUNCTION
RADIATION-THERAPY
RISK-FACTORS
MEDULLOBLASTOMA
CHILDREN
CANCER
ATTENTION
AGE
UNEMPLOYMENT
3112 Neurosciences
3124 Neurology and psychiatry
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