Neurocognitive impairment, employment, and social status in radiotherapy-treated adult survivors of childhood brain tumors

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Remes , T M , Hoven , E , Ritari , N , Pohjasniemi , H , Puosi , R , Arikoski , P M , Arola , M O , Lähteenmäki , P M , Lönnqvist , T R I , Ojaniemi , M K , Riikonen , V P , Sirkiä , K H , Winqvist , S , Rantala , H M J , Harila , M & Harila-Saari , A H 2021 , ' Neurocognitive impairment, employment, and social status in radiotherapy-treated adult survivors of childhood brain tumors ' , Neuro-Oncology practice , vol. 8 , no. 3 , pp. 266-277 . https://doi.org/10.1093/nop/npab004

Title: Neurocognitive impairment, employment, and social status in radiotherapy-treated adult survivors of childhood brain tumors
Author: Remes, Tiina M.; Hoven, Emma; Ritari, Niina; Pohjasniemi, Heli; Puosi, Riina; Arikoski, Pekka M.; Arola, Mikko O.; Lähteenmäki, Päivi M.; Lönnqvist, Tuula R. I.; Ojaniemi, Marja K.; Riikonen, V. Pekka; Sirkiä, Kirsti H.; Winqvist, Satu; Rantala, Heikki M. J.; Harila, Marika; Harila-Saari, Arja H.
Contributor organization: HUS Children and Adolescents
Lastenneurologian yksikkö
Children's Hospital
Clinicum
Date: 2021-06
Language: eng
Number of pages: 12
Belongs to series: Neuro-Oncology practice
ISSN: 2054-2577
DOI: https://doi.org/10.1093/nop/npab004
URI: http://hdl.handle.net/10138/333359
Abstract: Background. Little is known of the cognitive functions, employment, and social status in adult survivors of childhood brain tumor (BT). We aimed to determine the long-term neurocognitive profile of radiotherapy-treated adult survivors of childhood BT and the relationship between cognitive functions and employment and social status. Methods. Neurocognitive profiles of survivors were assessed in a Finnish national cohort of 71 radiotherapy-treated survivors of childhood BT (median follow-up time: 21 years [range: 5-33 years]) using a cross-sectional design. Neurocognitive outcomes were compared to control (n = 45) and normative values. Tumor- and treatment-related data were collected from the patient files. Information on employment and social status was gathered. Results. Survivors' (median age: 27 years [range: 16-43 years]) median verbal and performance intelligence quotient (IQ) was 90 (range: 49-121) and 87 (range: 43-119), respectively. The cognitive domains with the greatest impairment were executive functions (median z score, 3.5 SD [range: -25.0 to 1.3 SD]), and processing speed and attention (median z score, -2.5 SD [range: -24.9 to 0.5 SD]). Executive functions were associated with employment, educational level, living independently, having an intimate relationship, and having a driving license. Processing speed and attention were related to educational level, living independently, having an intimate relationship, and having a driving license. Performance IQ was associated with educational level and employment status. Working memory was associated with educational level and living independently. Conclusions. Radiotherapy-treated adult survivors of childhood BT experience significant neurocognitive impairment, which is associated with difficulties related to employment and social status.
Subject: brain tumor
employment
neurocognitive impairment
radiation
social status
WORKING-MEMORY
COGNITIVE FUNCTION
RADIATION-THERAPY
RISK-FACTORS
MEDULLOBLASTOMA
CHILDREN
CANCER
ATTENTION
AGE
UNEMPLOYMENT
3112 Neurosciences
3124 Neurology and psychiatry
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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