An Inverse Thermogelling Bioink Based on an ABA-Type Poly(2-oxazoline) Amphiphile

Näytä kaikki kuvailutiedot



Pysyväisosoite

http://hdl.handle.net/10138/333369

Lähdeviite

Hahn , L , Karakaya , E , Zorn , T , Sochor , B , Maier , M , Stahlhut , P , Forster , S , Fischer , K , Seiffert , S , Pöppler , A-C , Detsch , R & Luxenhofer , R 2021 , ' An Inverse Thermogelling Bioink Based on an ABA-Type Poly(2-oxazoline) Amphiphile ' , Biomacromolecules , vol. 22 , no. 7 , pp. 3017-3027 . https://doi.org/10.1021/acs.biomac.1c00427

Julkaisun nimi: An Inverse Thermogelling Bioink Based on an ABA-Type Poly(2-oxazoline) Amphiphile
Tekijä: Hahn, Lukas; Karakaya, Emine; Zorn, Theresa; Sochor, Benedikt; Maier, Matthias; Stahlhut, Philipp; Forster, Stefan; Fischer, Karl; Seiffert, Sebastian; Pöppler, Ann-Christin; Detsch, Rainer; Luxenhofer, Robert
Muu tekijä: University of Helsinki, Helsinki Institute of Sustainability Science (HELSUS)
Päiväys: 2021-07-12
Kieli: eng
Sivumäärä: 11
Kuuluu julkaisusarjaan: Biomacromolecules
ISSN: 1525-7797
URI: http://hdl.handle.net/10138/333369
Tiivistelmä: Hydrogels are key components in several biomedical research areas such as drug delivery, tissue engineering, and biofabrication. Here, a novel ABA-type triblock copolymer comprising poly(2-methyl-2-oxazoline) as the hydrophilic A blocks and poly(2-phenethyl-2-oxazoline) as the aromatic and hydrophobic B block is introduced. Above the critical micelle concentration, the polymer self-assembles into small spherical polymer micelles with a hydrodynamic radius of approx 8-8.5 nm. Interestingly, this specific combination of hydrophilic and hydrophobic aromatic moieties leads to rapid thermoresponsive inverse gelation at polymer concentrations above a critical gelation concentration (20 wt %) into a macroporous hydrogel of densely packed micelles. This hydrogel exhibited pronounced viscoelastic solid-like properties, as well as extensive shear-thinning, rapid structure recovery, and good strain resistance properties. Excellent 3D-printability of the hydrogel at lower temperature opens a wide range of different applications, for example, in the field of biofabrication. In preliminary bioprinting experiments using NIH 3T3 cells, excellent cell viabilities of more than 95% were achieved. The particularly interesting feature of this novel material is that it can be used as a printing support in hybrid bioink systems and sacrificial bioink due to rapid dissolution at physiological conditions.
Avainsanat: 116 Chemical sciences
Tekijänoikeustiedot:


Tiedostot

Latausmäärä yhteensä: Ladataan...

Tiedosto(t) Koko Formaatti Näytä
acs.biomac.1c00427.pdf 7.397MB PDF Avaa tiedosto

Viite kuuluu kokoelmiin:

Näytä kaikki kuvailutiedot