An Inverse Thermogelling Bioink Based on an ABA-Type Poly(2-oxazoline) Amphiphile

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dc.contributor University of Helsinki, Helsinki Institute of Sustainability Science (HELSUS) en Hahn, Lukas Karakaya, Emine Zorn, Theresa Sochor, Benedikt Maier, Matthias Stahlhut, Philipp Forster, Stefan Fischer, Karl Seiffert, Sebastian Pöppler, Ann-Christin Detsch, Rainer Luxenhofer, Robert 2021-08-20T14:55:02Z 2021-08-20T14:55:02Z 2021-07-12
dc.identifier.citation Hahn , L , Karakaya , E , Zorn , T , Sochor , B , Maier , M , Stahlhut , P , Forster , S , Fischer , K , Seiffert , S , Pöppler , A-C , Detsch , R & Luxenhofer , R 2021 , ' An Inverse Thermogelling Bioink Based on an ABA-Type Poly(2-oxazoline) Amphiphile ' , Biomacromolecules , vol. 22 , no. 7 , pp. 3017-3027 . en
dc.identifier.issn 1525-7797
dc.identifier.other PURE: 167751371
dc.identifier.other PURE UUID: 92bad8af-27ed-4300-9264-44b538a2496b
dc.identifier.other WOS: 000674171500021
dc.identifier.other Scopus: 85108584359
dc.identifier.other ORCID: /0000-0001-5567-7404/work/98752458
dc.description.abstract Hydrogels are key components in several biomedical research areas such as drug delivery, tissue engineering, and biofabrication. Here, a novel ABA-type triblock copolymer comprising poly(2-methyl-2-oxazoline) as the hydrophilic A blocks and poly(2-phenethyl-2-oxazoline) as the aromatic and hydrophobic B block is introduced. Above the critical micelle concentration, the polymer self-assembles into small spherical polymer micelles with a hydrodynamic radius of approx 8-8.5 nm. Interestingly, this specific combination of hydrophilic and hydrophobic aromatic moieties leads to rapid thermoresponsive inverse gelation at polymer concentrations above a critical gelation concentration (20 wt %) into a macroporous hydrogel of densely packed micelles. This hydrogel exhibited pronounced viscoelastic solid-like properties, as well as extensive shear-thinning, rapid structure recovery, and good strain resistance properties. Excellent 3D-printability of the hydrogel at lower temperature opens a wide range of different applications, for example, in the field of biofabrication. In preliminary bioprinting experiments using NIH 3T3 cells, excellent cell viabilities of more than 95% were achieved. The particularly interesting feature of this novel material is that it can be used as a printing support in hybrid bioink systems and sacrificial bioink due to rapid dissolution at physiological conditions. en
dc.format.extent 11
dc.language.iso eng
dc.relation.ispartof Biomacromolecules
dc.rights en
dc.subject 116 Chemical sciences en
dc.title An Inverse Thermogelling Bioink Based on an ABA-Type Poly(2-oxazoline) Amphiphile en
dc.type Article
dc.description.version Peer reviewed
dc.type.uri info:eu-repo/semantics/other
dc.type.uri info:eu-repo/semantics/publishedVersion

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