3D-printability of aqueous poly(ethylene oxide) gels

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http://hdl.handle.net/10138/333395

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Viidik , L , Seera , D , Antikainen , O , Kogermann , K , Heinämäki , J & Laidmäe , I 2019 , ' 3D-printability of aqueous poly(ethylene oxide) gels ' , European Polymer Journal , vol. 120 , 109206 . https://doi.org/10.1016/j.eurpolymj.2019.08.033

Titel: 3D-printability of aqueous poly(ethylene oxide) gels
Författare: Viidik, Laura; Seera, Dagmar; Antikainen, Osmo; Kogermann, Karin; Heinämäki, Jyrki; Laidmäe, Ivo
Upphovmannens organisation: Division of Pharmaceutical Chemistry and Technology
Datum: 2019-11
Språk: eng
Sidantal: 10
Tillhör serie: European Polymer Journal
ISSN: 0014-3057
DOI: https://doi.org/10.1016/j.eurpolymj.2019.08.033
Permanenta länken (URI): http://hdl.handle.net/10138/333395
Abstrakt: Printing technologies combined with a computer-aided design (CAD) have found an increasing number of uses in pharmaceutical applications. In extrusion-based printing, the material is forced through a nozzle to form a three-dimensional (3D) structure pre-designed by CAD. The aim of this study was to evaluate the 3D-printability of biocompatible aqueous poly(ethylene oxide) (PEO) gels and to investigate the effects of three formulation parameters on the 3D printing process. The impact of PEO concentration (gel viscosity), printing head speed and printing plate temperature was investigated at three different levels using a full factorial experimental design. The aqueous PEO gels were printed with a bench-top extrusion-based 3D printing system at an ambient room temperature. The viscosity measurements confirmed that the aqueous PEO gels follow a shear-thinning behaviour suitable for extrusion-based printing. Heating the printing plate allowed the gel to dry faster resulting in more precise printing outcome. With the non-heated plate, the gel formed a dumbbell-shaped grid instead of straight lines. Higher concentration and more viscous PEO gels formed the best structured 3D-printed lattices. In conclusion, the accuracy and precision of extrusion-based 3D printing of aqueous PEO gels is highly dependent on the formulation (PEO concentration) and printing parameters (printing head speed, plate temperature). By optimizing these critical process parameters, PEO may be suitable for printing novel drug delivery systems.
Subject: 3D PRINTING TECHNOLOGY
BEHAVIOR
BLENDS
Drug delivery system
Extrusion-based 3D printing
Gel
HYDROGEL
POLYETHYLENE OXIDE
Poly(ethylene oxide)
Process parameters
TABLETS
THERMAL-DEGRADATION
Viscosity
317 Pharmacy
116 Chemical sciences
Referentgranskad: Ja
Licens: cc_by_nc_nd
Användningsbegränsning: openAccess
Parallelpublicerad version: acceptedVersion


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