3D-printability of aqueous poly(ethylene oxide) gels

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dc.contributor.author Viidik, Laura
dc.contributor.author Seera, Dagmar
dc.contributor.author Antikainen, Osmo
dc.contributor.author Kogermann, Karin
dc.contributor.author Heinämäki, Jyrki
dc.contributor.author Laidmäe, Ivo
dc.date.accessioned 2021-08-22T21:55:06Z
dc.date.available 2021-12-18T03:45:23Z
dc.date.issued 2019-11
dc.identifier.citation Viidik , L , Seera , D , Antikainen , O , Kogermann , K , Heinämäki , J & Laidmäe , I 2019 , ' 3D-printability of aqueous poly(ethylene oxide) gels ' , European Polymer Journal , vol. 120 , 109206 . https://doi.org/10.1016/j.eurpolymj.2019.08.033
dc.identifier.other PURE: 126388397
dc.identifier.other PURE UUID: 32eefb06-05fa-478a-9c0f-e14eb7ed17b2
dc.identifier.other RIS: urn:58E78DDB803F9D48768C2E8D5E10652F
dc.identifier.other WOS: 000498309000025
dc.identifier.uri http://hdl.handle.net/10138/333395
dc.description.abstract Printing technologies combined with a computer-aided design (CAD) have found an increasing number of uses in pharmaceutical applications. In extrusion-based printing, the material is forced through a nozzle to form a three-dimensional (3D) structure pre-designed by CAD. The aim of this study was to evaluate the 3D-printability of biocompatible aqueous poly(ethylene oxide) (PEO) gels and to investigate the effects of three formulation parameters on the 3D printing process. The impact of PEO concentration (gel viscosity), printing head speed and printing plate temperature was investigated at three different levels using a full factorial experimental design. The aqueous PEO gels were printed with a bench-top extrusion-based 3D printing system at an ambient room temperature. The viscosity measurements confirmed that the aqueous PEO gels follow a shear-thinning behaviour suitable for extrusion-based printing. Heating the printing plate allowed the gel to dry faster resulting in more precise printing outcome. With the non-heated plate, the gel formed a dumbbell-shaped grid instead of straight lines. Higher concentration and more viscous PEO gels formed the best structured 3D-printed lattices. In conclusion, the accuracy and precision of extrusion-based 3D printing of aqueous PEO gels is highly dependent on the formulation (PEO concentration) and printing parameters (printing head speed, plate temperature). By optimizing these critical process parameters, PEO may be suitable for printing novel drug delivery systems. en
dc.format.extent 10
dc.language.iso eng
dc.relation.ispartof European Polymer Journal
dc.rights cc_by_nc_nd
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject BEHAVIOR
dc.subject BLENDS
dc.subject Drug delivery system
dc.subject Extrusion-based 3D printing
dc.subject Gel
dc.subject HYDROGEL
dc.subject Poly(ethylene oxide)
dc.subject Process parameters
dc.subject TABLETS
dc.subject Viscosity
dc.subject 317 Pharmacy
dc.subject 116 Chemical sciences
dc.title 3D-printability of aqueous poly(ethylene oxide) gels en
dc.type Article
dc.contributor.organization Division of Pharmaceutical Chemistry and Technology
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1016/j.eurpolymj.2019.08.033
dc.relation.issn 0014-3057
dc.rights.accesslevel openAccess
dc.type.version acceptedVersion

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