Prediabetes/diabetes screening strategy at the periodontal clinic

Show full item record



Permalink

http://hdl.handle.net/10138/333558

Citation

Grigoriadis , A , Räisänen , I T , Pärnänen , P , Tervahartiala , T , Sorsa , T & Sakellari , D 2021 , ' Prediabetes/diabetes screening strategy at the periodontal clinic ' , Clinical and Experimental Dental Research , vol. 7 , no. 1 , pp. 85-92 . https://doi.org/10.1002/cre2.338

Title: Prediabetes/diabetes screening strategy at the periodontal clinic
Author: Grigoriadis, Andreas; Räisänen, Ismo T.; Pärnänen, Pirjo; Tervahartiala, Taina; Sorsa, Timo; Sakellari, Dimitra
Contributor: University of Helsinki, Department of Oral and Maxillofacial Diseases
University of Helsinki, HUS Head and Neck Center
University of Helsinki, HUS Head and Neck Center
University of Helsinki, HUS Head and Neck Center
Date: 2021-02
Language: eng
Number of pages: 8
Belongs to series: Clinical and Experimental Dental Research
ISSN: 2057-4347
URI: http://hdl.handle.net/10138/333558
Abstract: Objective: The aim of the study was to propose an efficient chairside clinical strategy for the identification of undiagnosed hyperglycaemia in periodontal clinics. Material and methods: Alpha chairside system was used for assessment of glycated hemoglobin 1c (HbA1c) and active Matrix Metalloproteinase-8 levels (aMMP-8) were analyzed by immunotest in patients (n = 150) who fulfilled the criteria for screening of the Centers for Disease Control and Prevention. Full-mouth periodontal parameters were assessed and various data such as Body Mass Index (BMI), smoking and education were recorded. Results: Thirty-one patients out of 150 tested were found with unknown hyperglycaemia (20.7%). Regarding sex, education, parent with diabetes, normal BMI, smoking, age >= 45 years and prior testing for diabetes, no differences were observed between subjects displaying HbA1c <5.7 and >= 5.7% (Pearson's Chi-square test, p > .05). Subgroups differed regarding BMI (kg/m(2)), tooth count, percentages of 4 and 5 mm pockets (Mann-Whitney and z-test, p <.05). The diagnostic performance for HbA1c >= 5.7 was tested by Receiving Operator Characteristic curves and Areas Under the Curve (AUC) for the following: age >= 45 years and BMI (AUC 0.651, p = .010), the above and aMMP-8 (AUC 0.660, p = .006), age >= 45 years, BMI and Stage of Periodontitis (AUC 0.711, p <.001) and age >= 45 years, BMI, aMMP-8 and stage of periodontitis (AUC 0.713, p <.001). Conclusions: Findings of the study suggest that the combination of stage of periodontitis, increasing age, BMI and aMMP-8, without chairside HbA1c assessment appears to be a viable screening strategy for referring dental patients for testing for prediabetes/diabetes.
Subject: diabetes
diagnosis
matrix metalloproteinase
GINGIVAL CREVICULAR FLUID
DIABETES-MELLITUS
CONSENSUS REPORT
ORAL-HEALTH
RISK
CLASSIFICATION
IDENTIFICATION
PREVALENCE
WORKSHOP
DISEASES
313 Dentistry
Rights:


Files in this item

Total number of downloads: Loading...

Files Size Format View
cre2.338_1_.pdf 994.8Kb PDF View/Open

This item appears in the following Collection(s)

Show full item record