Relationship Between Anticholinergic Burden and Health-Related Quality of Life Among Residents in Long-Term Care

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http://hdl.handle.net/10138/333588

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Aalto , U L , Finne-Soveri , H , Kautiainen , H , Öhman , H , Roitto , H-M & Pitkälä , K H 2021 , ' Relationship Between Anticholinergic Burden and Health-Related Quality of Life Among Residents in Long-Term Care ' , The journal of nutrition, health & aging , vol. 25 , no. 2 , pp. 224–229 . https://doi.org/10.1007/s12603-020-1493-2

Title: Relationship Between Anticholinergic Burden and Health-Related Quality of Life Among Residents in Long-Term Care
Author: Aalto, Ulla L.; Finne-Soveri, H.; Kautiainen, H.; Öhman, H.; Roitto, H.-M.; Pitkälä, K. H.
Contributor: University of Helsinki, Department of General Practice and Primary Health Care
University of Helsinki, Department of General Practice and Primary Health Care
University of Helsinki, Department of Medicine
University of Helsinki, Department of General Practice and Primary Health Care
University of Helsinki, Department of General Practice and Primary Health Care
Date: 2021-02
Language: eng
Number of pages: 6
Belongs to series: The journal of nutrition, health & aging
ISSN: 1760-4788
URI: http://hdl.handle.net/10138/333588
Abstract: Objectives Anticholinergic burden defined by the Anticholinergic Risk Scale (ARS) has been associated with cognitive and functional decline. Associations with health-related quality of life (HRQoL) have been scarcely studied. The aim of this study was to examine the association between anticholinergic burden and HRQoL among older people living in long-term care. Further, we investigated whether there is an interaction between ARS score and HRQoL in certain underlying conditions. Design and participants Cross-sectional study in 2017. Participants were older people residing in long-term care facilities (N=2474) in Helsinki. Measurements Data on anticholinergic burden was assessed by ARS score, nutritional status by Mini Nutritional Assessment, and HRQoL by the 15D instrument. Results Of the participants, 54% regularly used ARS-defined drugs, and 22% had ARS scores >= 2. Higher ARS scores were associated with better cognition, functioning, nutritional status and higher HRQoL. When viewing participants separately according to a diagnosis of dementia, nutritional status or level of dependency, HRQoL was lower among those having dementia, worse nutritional status, or being dependent on another person's help (adjusted for age, sex, comorbidities). Significant differences within the groups according to ARS score were no longer observed. However, interactions between ARS score and dementia and dependency emerged. Conclusion In primary analysis there was an association between ARS score and HRQoL. However, this relationship disappeared after stratification by dementia, nutritional status and dependency. The reasons behind the interaction concerning dementia or dependency remain unclear and warrant further studies.
Subject: 3143 Nutrition
3142 Public health care science, environmental and occupational health
Anticholinergic burden
long-term care
nursing home
HRQoL
dementia
NURSING-HOME RESIDENTS
CROSS-SECTIONAL ANALYSIS
OLDER-PEOPLE
MEDICATION USE
RISK SCALE
DRUG-USE
ASSOCIATION
DEMENTIA
OUTCOMES
BENEFICIARIES
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