Efficacy of broccoli and glucoraphanin in COVID-19: From hypothesis to proof-of-concept with three experimental clinical cases

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dc.contributor.author Bousquet, Jean
dc.contributor.author Le Moing, Vincent
dc.contributor.author Blain, Hubert
dc.contributor.author Czarlewski, Wienczyslawa
dc.contributor.author Zuberbier, Torsten
dc.contributor.author Torre, Raphael de la
dc.contributor.author Lozano, Nieves Pizarro
dc.contributor.author Reynes, Jacques
dc.contributor.author Bedbrook, Anna
dc.contributor.author Cristol, Jean-Paul
dc.contributor.author Cruz, Alvaro A.
dc.contributor.author Fiocchi, Alessandro
dc.contributor.author Haahtela, Tari
dc.contributor.author Iaccarino, Guido
dc.contributor.author Klimek, Ludger
dc.contributor.author Kuna, Piotr
dc.contributor.author Melén, Erik
dc.contributor.author Mullol, Joaquim
dc.contributor.author Samolinski, Boleslaw
dc.contributor.author Valiulis, Arunas
dc.contributor.author Anto, Josep M.
dc.date.accessioned 2021-08-25T22:04:06Z
dc.date.available 2021-08-25T22:04:06Z
dc.date.issued 2021-01
dc.identifier.citation Bousquet , J , Le Moing , V , Blain , H , Czarlewski , W , Zuberbier , T , Torre , R D L , Lozano , N P , Reynes , J , Bedbrook , A , Cristol , J-P , Cruz , A A , Fiocchi , A , Haahtela , T , Iaccarino , G , Klimek , L , Kuna , P , Melén , E , Mullol , J , Samolinski , B , Valiulis , A & Anto , J M 2021 , ' Efficacy of broccoli and glucoraphanin in COVID-19: From hypothesis to proof-of-concept with three experimental clinical cases ' , World Allergy Organization journal , vol. 14 , no. 1 , 100498 . https://doi.org/10.1016/j.waojou.2020.100498
dc.identifier.other PURE: 157227334
dc.identifier.other PURE UUID: 8218b0ec-e7e6-4e9f-91e3-de8fadb0b04d
dc.identifier.other RIS: urn:D9C7319A889D1595B237EC884B59E1A3
dc.identifier.other WOS: 000698686200007
dc.identifier.uri http://hdl.handle.net/10138/333628
dc.description.abstract COVID-19 is described in a clinical case involving a patient who proposed the hypothesis that Nuclear factor (erythroid-derived 2)-like 2 (Nrf2)-interacting nutrients may help to prevent severe COVID-19 symptoms. Capsules of broccoli seeds containing glucoraphanin were being taken before the onset of SARS-CoV-2 infection and were continued daily for over a month after the first COVID-19 symptoms. They were found to reduce many of the symptoms rapidly and for a duration of 6-12 h by repeated dosing. When the patient was stable but still suffering from cough and nasal obstruction when not taking the broccoli capsules, a double-blind induced cough challenge confirmed the speed of onset of the capsules (less than 10 min). A second clinical case with lower broccoli doses carried out during the cytokine storm confirmed the clinical benefits already observed. A third clinical case showed similar effects at the onset of symptoms. In the first clinical trial, we used a dose of under 600 mmol per day of glucoraphanin. However, such a high dose may induce pharmacologic effects that require careful examination before the performance of any study. It is likely that the fast onset of action is mediated through the TRPA1 channel. These experimental clinical cases represent a proof-of-concept confirming the hypothesis that Nrf2interacting nutrients are effective in COVID-19. However, this cannot be used in practice before the availability of further safety data, and confirmation is necessary through proper trials on efficacy and safety. en
dc.format.extent 16
dc.language.iso eng
dc.relation.ispartof World Allergy Organization journal
dc.rights cc_by
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject 3121 General medicine, internal medicine and other clinical medicine
dc.subject COVID-19
dc.subject Nrf2
dc.subject broccoli
dc.subject cough challenge
dc.subject TRPA1
dc.subject TRPV1
dc.subject ACTIVATION
dc.subject MECHANISM
dc.subject SULFORAPHANE
dc.subject STRATEGY
dc.subject CHEMOPREVENTION
dc.subject INDUCED CARDIOMYOPATHY
dc.subject Cough challenge
dc.subject RHINITIS
dc.subject Broccoli
dc.subject NRF2
dc.subject RICH
dc.subject COUGH
dc.title Efficacy of broccoli and glucoraphanin in COVID-19: From hypothesis to proof-of-concept with three experimental clinical cases en
dc.type Article
dc.contributor.organization Department of Dermatology, Allergology and Venereology
dc.contributor.organization HUS Inflammation Center
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1016/j.waojou.2020.100498
dc.relation.issn 1939-4551
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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