Increased Brain Reward Responsivity to Food-Related Odors in Obesity.

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dc.contributor University of Helsinki, O'BRAIN Lab en
dc.contributor.author Han, Pengfei
dc.contributor.author Roitzsch, Clemens
dc.contributor.author Horstmann, Annette
dc.contributor.author Pössel, Maria
dc.contributor.author Hummel, Thomas
dc.date.accessioned 2021-08-26T04:42:02Z
dc.date.available 2021-08-26T04:42:02Z
dc.date.issued 2021-07
dc.identifier.citation Han , P , Roitzsch , C , Horstmann , A , Pössel , M & Hummel , T 2021 , ' Increased Brain Reward Responsivity to Food-Related Odors in Obesity. ' , Obesity , vol. 29 , no. 7 , pp. 1138-1145 . https://doi.org/10.1002/oby.23170 en
dc.identifier.issn 1071-7323
dc.identifier.other PURE: 165628273
dc.identifier.other PURE UUID: c3f91550-d6dc-4d53-ac15-52001f6aacdd
dc.identifier.other WOS: 000645042900001
dc.identifier.other ORCID: /0000-0001-6184-8484/work/98976615
dc.identifier.uri http://hdl.handle.net/10138/333630
dc.description.abstract Objective Food odors serve as powerful stimuli signaling the food quality and energy density and direct food-specific appetite and consumption. This study explored obesity-related brain activation in response to odors related to high- or low-energy-dense foods. Methods Seventeen participants with obesity (BMI > 30 kg/m2 ; 4 males and 13 females) and twenty-one with normal weight (BMI < 25 kg/m2 ; 9 males and 12 females) underwent a functional magnetic resonance imaging scan in which they received chocolate (high-energy-dense food) and cucumber (low-energy-dense food) odor stimuli. Participants' olfactory and gustatory functions were assessed by the "Sniffin' Sticks" and "Taste Strips" tests, respectively. Results Compared with normal-weight controls, participants with obesity had lower odor sensitivity (phenylethyl alcohol) and decreased odor discrimination ability. However, participants with obesity demonstrated greater brain activation in response to chocolate compared with cucumber odors in the bilateral inferior frontal operculum and cerebellar vermis, right ventral anterior insula extending to putamen, right middle temporal gyrus, and right supramarginal areas. Conclusions The present study provides preliminary evidence that obesity is associated with heightened brain activation of the reward and flavor processing areas in response to chocolate versus cucumber odors, possibly because of the higher energy density and reinforcing value of chocolate compared with cucumber. en
dc.format.extent 8
dc.language.iso eng
dc.relation.ispartof Obesity
dc.rights en
dc.subject 3121 General medicine, internal medicine and other clinical medicine en
dc.subject 3143 Nutrition en
dc.title Increased Brain Reward Responsivity to Food-Related Odors in Obesity. en
dc.type Article
dc.description.version Peer reviewed
dc.identifier.doi https://doi.org/10.1002/oby.23170
dc.type.uri info:eu-repo/semantics/other
dc.type.uri info:eu-repo/semantics/publishedVersion
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