Utilising Induced Pluripotent Stem Cells in Neurodegenerative Disease Research: Focus on Glia

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Albert , K , Niskanen , J , Kälvälä , S & Lehtonen , Š 2021 , ' Utilising Induced Pluripotent Stem Cells in Neurodegenerative Disease Research: Focus on Glia ' , International Journal of Molecular Sciences , vol. 22 , no. 9 , 4334 . https://doi.org/10.3390/ijms22094334

Title: Utilising Induced Pluripotent Stem Cells in Neurodegenerative Disease Research: Focus on Glia
Author: Albert, Katrina; Niskanen, Jonna; Kälvälä, Sara; Lehtonen, Šárka
Contributor: University of Helsinki, Neuroscience Center
Date: 2021-05
Language: eng
Number of pages: 28
Belongs to series: International Journal of Molecular Sciences
ISSN: 1422-0067
URI: http://hdl.handle.net/10138/333638
Abstract: Induced pluripotent stem cells (iPSCs) are a self-renewable pool of cells derived from an organism’s somatic cells. These can then be programmed to other cell types, including neurons. Use of iPSCs in research has been two-fold as they have been used for human disease modelling as well as for the possibility to generate new therapies. Particularly in complex human diseases, such as neurodegenerative diseases, iPSCs can give advantages over traditional animal models in that they more accurately represent the human genome. Additionally, patient-derived cells can be modified using gene editing technology and further transplanted to the brain. Glial cells have recently become important avenues of research in the field of neurodegenerative diseases, for example, in Alzheimer’s disease and Parkinson’s disease. This review focuses on using glial cells (astrocytes, microglia, and oligodendrocytes) derived from human iPSCs in order to give a better understanding of how these cells contribute to neurodegenerative disease pathology. Using glia iPSCs in in vitro cell culture, cerebral organoids, and intracranial transplantation may give us future insight into both more accurate models and disease-modifying therapies.
Subject: 3112 Neurosciences
1182 Biochemistry, cell and molecular biology
astrocytes
microglia
oligodendrocytes
induced pluripotent stem cells
transplantation
organoids
neurodegenerative disease
humanized models
NEURAL PROGENITOR CELLS
FETAL MESENCEPHALIC TISSUE
PARKINSONS-DISEASE
ALZHEIMERS-DISEASE
TRANSGENIC MICE
IN-VIVO
EFFICIENT GENERATION
ASTROCYTE DYSFUNCTION
DOPAMINERGIC-NEURONS
FUNCTIONAL RECOVERY
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