Selenium Nanoparticles for Biomedical Applications: From Development and Characterization to Therapeutics

Show full item record



Permalink

http://hdl.handle.net/10138/333666

Citation

Ferro , C , Florindo , H & Santos , H A 2021 , ' Selenium Nanoparticles for Biomedical Applications: From Development and Characterization to Therapeutics ' , Advanced Healthcare Materials , vol. 10 , no. 16 , 2100598 . https://doi.org/10.1002/adhm.202100598

Title: Selenium Nanoparticles for Biomedical Applications: From Development and Characterization to Therapeutics
Author: Ferro, Claudio; Florindo, Helena; Santos, Hélder A.
Contributor: University of Helsinki, Helsinki One Health (HOH)
Date: 2021-08
Language: eng
Number of pages: 50
Belongs to series: Advanced Healthcare Materials
ISSN: 2192-2640
URI: http://hdl.handle.net/10138/333666
Abstract: Selenium (Se) is an essential element to human health that can be obtained in nature through several sources. In the human body, it is incorporated into selenocysteine, an amino acid used to synthesize several selenoproteins, which have an active center usually dependent on the presence of Se. Although Se shows several beneficial properties in human health, it has also a narrow therapeutic window, and therefore the excessive intake of inorganic and organic Se-based compounds often leads to toxicity. Nanoparticles based on Se (SeNPs) are less toxic than inorganic and organic Se. They are both biocompatible and capable of effectively delivering combinations of payloads to specific cells following their functionalization with active targeting ligands. Herein, the main origin of Se intake, its role on the human body, and its primary biomedical applications are revised. Particular focus will be given to the main therapeutic targets that are explored for SeNPs in cancer therapies, discussing the different functionalization methodologies used to improve SeNPs stability, while enabling the extensive delivery of drug-loaded SeNP to tumor sites, thus avoiding off-target effects.
Subject: 116 Chemical sciences
318 Medical biotechnology
221 Nano-technology
3111 Biomedicine
biomedicine
cancer
reactive oxidative species
selenium nanoparticles
AMYLOID-BETA AGGREGATION
SELECTIVE CELLULAR UPTAKE
IN-VIVO SYNTHESIS
CANCER-CELLS
ANTICANCER EFFICACY
HYALURONIC-ACID
NANO-SELENIUM
PHYSICOCHEMICAL CHARACTERIZATION
SYNERGISTIC COMBINATION
ANTIBACTERIAL ACTIVITY
Rights:


Files in this item

Total number of downloads: Loading...

Files Size Format View
adhm.202100598.pdf 9.305Mb PDF View/Open
Selenium_Nanopa ... zation_to_Therapeutics.pdf 9.304Mb PDF View/Open

This item appears in the following Collection(s)

Show full item record