Ferro , C , Florindo , H & Santos , H A 2021 , ' Selenium Nanoparticles for Biomedical Applications: From Development and Characterization to Therapeutics ' , Advanced Healthcare Materials , vol. 10 , no. 16 , 2100598 . https://doi.org/10.1002/adhm.202100598
Title: | Selenium Nanoparticles for Biomedical Applications: From Development and Characterization to Therapeutics |
Author: | Ferro, Claudio; Florindo, Helena; Santos, Hélder A. |
Contributor organization: | Helsinki One Health (HOH) Drug Research Program Divisions of Faculty of Pharmacy Division of Pharmaceutical Chemistry and Technology Nanomedicines and Biomedical Engineering Helsinki Institute of Life Science HiLIFE |
Date: | 2021-08 |
Language: | eng |
Number of pages: | 50 |
Belongs to series: | Advanced Healthcare Materials |
ISSN: | 2192-2640 |
DOI: | https://doi.org/10.1002/adhm.202100598 |
URI: | http://hdl.handle.net/10138/333666 |
Abstract: | Selenium (Se) is an essential element to human health that can be obtained in nature through several sources. In the human body, it is incorporated into selenocysteine, an amino acid used to synthesize several selenoproteins, which have an active center usually dependent on the presence of Se. Although Se shows several beneficial properties in human health, it has also a narrow therapeutic window, and therefore the excessive intake of inorganic and organic Se-based compounds often leads to toxicity. Nanoparticles based on Se (SeNPs) are less toxic than inorganic and organic Se. They are both biocompatible and capable of effectively delivering combinations of payloads to specific cells following their functionalization with active targeting ligands. Herein, the main origin of Se intake, its role on the human body, and its primary biomedical applications are revised. Particular focus will be given to the main therapeutic targets that are explored for SeNPs in cancer therapies, discussing the different functionalization methodologies used to improve SeNPs stability, while enabling the extensive delivery of drug-loaded SeNP to tumor sites, thus avoiding off-target effects. |
Subject: |
116 Chemical sciences
318 Medical biotechnology 221 Nano-technology 3111 Biomedicine biomedicine cancer reactive oxidative species selenium nanoparticles AMYLOID-BETA AGGREGATION SELECTIVE CELLULAR UPTAKE IN-VIVO SYNTHESIS CANCER-CELLS ANTICANCER EFFICACY HYALURONIC-ACID NANO-SELENIUM PHYSICOCHEMICAL CHARACTERIZATION SYNERGISTIC COMBINATION ANTIBACTERIAL ACTIVITY |
Peer reviewed: | Yes |
Rights: | cc_by |
Usage restriction: | openAccess |
Self-archived version: | publishedVersion |
Total number of downloads: Loading...
Files | Size | Format | View |
---|---|---|---|
adhm.202100598.pdf | 9.305Mb |
View/ |
|
Selenium_Nanopa ... zation_to_Therapeutics.pdf | 9.304Mb |
View/ |