Compounding Parenteral Products in Pediatric Wards—Effect of Environment and Aseptic Technique on Product Sterility

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dc.contributor.author Virtanen, Sonja
dc.contributor.author Kapp, Karmen
dc.contributor.author Rautamo, Maria
dc.contributor.author Schepel, Lotta
dc.contributor.author Lindén-Lahti, Carita
dc.contributor.author Cruz, Cristina D.
dc.contributor.author Tammela, Päivi
dc.date.accessioned 2021-08-26T13:27:04Z
dc.date.available 2021-08-26T13:27:04Z
dc.date.issued 2021-08-10
dc.identifier.citation Virtanen, S.; Kapp, K.; Rautamo, M.; Schepel, L.; Lindén-Lahti, C.; Cruz, C.D.; Tammela, P. Compounding Parenteral Products in Pediatric Wards—Effect of Environment and Aseptic Technique on Product Sterility. Healthcare 2021, 9, 1025.
dc.identifier.uri http://hdl.handle.net/10138/333669
dc.description.abstract Parenteral products must be compounded using an aseptic technique to ensure sterility of the medicine. We compared the effect of three clinical environments as compounding areas as well as different aseptic techniques on the sterility of the compounded parenteral product. Clinical pharmacists and pediatric nurses compounded 220 samples in total in three clinical environments: a patient room, a medicine room and biological safety cabinet. The study combined four methods: observation, environmental monitoring (settle plates), monitoring of personnel (finger dab plates) and sterility testing (membrane filtration). Of the compounded samples, 99% were sterile and no significant differences emerged between the clinical environments. Based on the settle plates, the biological safety cabinet was the only area that fulfilled the requirements for eliminating microbial contamination. Most of the steps on the observation form for aseptic techniques were followed. All participants disinfected their hands, wore gloves and disinfected the septum of the vial. Non-contaminated finger dab plates were mostly detected after compounding in the biological safety cabinet. Aseptic techniques were followed relatively well in all environments. However, these results emphasize the importance of good aseptic techniques and support the recommendation of compounding parenteral products in biological safety cabinets in clinical environments.
dc.publisher Multidisciplinary Digital Publishing Institute
dc.title Compounding Parenteral Products in Pediatric Wards—Effect of Environment and Aseptic Technique on Product Sterility
dc.date.updated 2021-08-26T13:27:04Z
dc.type.uri http://purl.org/eprint/entityType/JournalArticle
dc.type.uri http://purl.org/eprint/entityType/Expression
dc.type.uri http://purl.org/eprint/entityType/Expression

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