In Vivo and In Vitro Antidiabetic and Anti-Inflammatory Properties of Flax (Linum usitatissimum L.) Seed Polyphenols

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dc.contributor.author Mechchate, Hamza
dc.contributor.author Es-safi, Imane
dc.contributor.author Conte, Raffaele
dc.contributor.author Hano, Christophe
dc.contributor.author Amaghnouje, Amal
dc.contributor.author Jawhari, Fatima Zahra
dc.contributor.author Radouane, Nabil
dc.contributor.author Bencheikh, Noureddine
dc.contributor.author Grafov, Andriy
dc.contributor.author Bousta, Dalila
dc.date.accessioned 2021-08-26T13:27:05Z
dc.date.available 2021-08-26T13:27:05Z
dc.date.issued 2021-08-11
dc.identifier.citation Mechchate, H.; Es-safi, I.; Conte, R.; Hano, C.; Amaghnouje, A.; Jawhari, F.Z.; Radouane, N.; Bencheikh, N.; Grafov, A.; Bousta, D. In Vivo and In Vitro Antidiabetic and Anti-Inflammatory Properties of Flax (Linum usitatissimum L.) Seed Polyphenols. Nutrients 2021, 13, 2759.
dc.identifier.uri http://hdl.handle.net/10138/333670
dc.description.abstract Flaxseed is an oilseed (45–50% oil on a dry-weight basis) crop. Its oil has demonstrated multiple health benefits and industrial applications. The goal of this research was to evaluate the antidiabetic and anti-inflammatory potential of the free polyphenol fraction of flax (<i>Linum usitatissimum</i> L.) seeds (PLU), based on their use in traditional medicine. Mice with alloxan-induced diabetes were used to study the antidiabetic activity of PLU in vivo, with an oral administration of 25 and 50 mg/kg over 28 days. Measurements of body weight and fasting blood glucose (FBG) were carried out weekly, and biochemical parameters were evaluated. An oral glucose tolerance test was also performed. Inhibitory activities of PLU on α-amylase and α-glucosidase activities were evaluated in vitro. The anti-inflammatory was evaluated in vivo in Wistar rats using the paw edema induction Test by carrageenan, and in vitro using the hemolysis ratio test. PLU administration to diabetic mice during the study period improved their body weight and FBG levels remarkably. In vitro inhibitory activity of digestive enzymes indicated that they may be involved in the proposed mode of action of PLU extract. Qualitative results of PLU revealed the presence of 18 polyphenols. These findings support daily consumption of flaxseed for people with diabetes, and suggest that polyphenols in flaxseed may serve as dietary supplements or novel phytomedicines to treat diabetes and its complications.
dc.language.iso en
dc.publisher Multidisciplinary Digital Publishing Institute
dc.title In Vivo and In Vitro Antidiabetic and Anti-Inflammatory Properties of Flax (Linum usitatissimum L.) Seed Polyphenols en
dc.date.updated 2021-08-26T13:27:05Z
dc.type.uri http://purl.org/eprint/entityType/JournalArticle
dc.type.uri http://purl.org/eprint/entityType/Expression
dc.type.uri http://purl.org/eprint/entityType/Expression

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