New 2,3-Benzodiazepine Derivative: Synthesis, Activity on Central Nervous System, and Toxicity Study in Mice

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dc.contributor.author Amaghnouje, Amal
dc.contributor.author Bohza, Serhii
dc.contributor.author Bohdan, Nathalie
dc.contributor.author Es-Safi, Imane
dc.contributor.author Kyrylchuk, Andrii
dc.contributor.author Achour, Sanae
dc.contributor.author El Fatemi, Hinde
dc.contributor.author Bousta, Dalila
dc.contributor.author Grafov, Andriy
dc.date.accessioned 2021-08-26T13:27:42Z
dc.date.available 2021-08-26T13:27:42Z
dc.date.issued 2021-08-19
dc.identifier.citation Amaghnouje, A.; Bohza, S.; Bohdan, N.; Es-Safi, I.; Kyrylchuk, A.; Achour, S.; El Fatemi, H.; Bousta, D.; Grafov, A. New 2,3-Benzodiazepine Derivative: Synthesis, Activity on Central Nervous System, and Toxicity Study in Mice. Pharmaceuticals 2021, 14, 814.
dc.identifier.uri http://hdl.handle.net/10138/333681
dc.description.abstract We report the design and synthesis of a new diazepine derivative, 4-(4-methoxyphenyl)-2,3,4,5-tetrahydro-2,3-benzodiazepin-1-one (VBZ102), and the evaluation of its anxiolytic-like profile, memory impairment effect, and toxicity in Swiss mice. VBZ102 was evaluated for central nervous system effects in an open field, light–dark box, and novel object recognition tests under oral administration for acute and sub-acute treatment. We tested the VBZ102 toxicity in mice through a determination of LD<sub>50</sub> values and examination of the biochemical and histopathological parameters. The VBZ102 induced an anxiolytic effect at different doses both in the light–dark box and open field tests. Unlike other benzodiazepines (e.g., bromazepam), a sedative effect was noted only after administration of the VBZ102 at 10.0 mg/kg.
dc.publisher Multidisciplinary Digital Publishing Institute
dc.title New 2,3-Benzodiazepine Derivative: Synthesis, Activity on Central Nervous System, and Toxicity Study in Mice
dc.date.updated 2021-08-26T13:27:42Z
dc.type.uri http://purl.org/eprint/entityType/JournalArticle
dc.type.uri http://purl.org/eprint/entityType/Expression
dc.type.uri http://purl.org/eprint/entityType/Expression

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