The Association Between High Birth Weight and Long-Term Outcomes-Implications for Assisted Reproductive Technologies : A Systematic Review and Meta-Analysis

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Magnusson , Å , Laivuori , H , Loft , A , Oldereid , N B , Pinborg , A , Petzold , M , Romundstad , L B , Söderström-Anttila , V & Bergh , C 2021 , ' The Association Between High Birth Weight and Long-Term Outcomes-Implications for Assisted Reproductive Technologies : A Systematic Review and Meta-Analysis ' , Frontiers in pediatrics , vol. 9 , 675775 . https://doi.org/10.3389/fped.2021.675775

Title: The Association Between High Birth Weight and Long-Term Outcomes-Implications for Assisted Reproductive Technologies : A Systematic Review and Meta-Analysis
Author: Magnusson, Åsa; Laivuori, Hannele; Loft, Anne; Oldereid, Nan B.; Pinborg, Anja; Petzold, Max; Romundstad, Liv Bente; Söderström-Anttila, Viveca; Bergh, Christina
Contributor: University of Helsinki, HUS Gynecology and Obstetrics
University of Helsinki, Clinicum
Date: 2021-06-23
Language: eng
Number of pages: 43
Belongs to series: Frontiers in pediatrics
ISSN: 2296-2360
URI: http://hdl.handle.net/10138/333916
Abstract: Background: Studies have shown that the prevalence of children born with high birth weight or large for gestational age (LGA) is increasing. This is true for spontaneous pregnancies; however, children born after frozen embryo transfer (FET) as part of assisted reproductive technology (ART) also have an elevated risk. In recent years, the practice of FET has increased rapidly and while the perinatal and obstetric risks are well-studied, less is known about the long-term health consequences. Objective: The aim of this systematic review was to describe the association between high birth weight and LGA on long-term child outcomes. Data Sources: PubMed, Scopus, and Web of Science were searched up to January 2021. Exposure included high birth weight and LGA. Long-term outcome variables included malignancies, psychiatric disorders, cardiovascular disease, and diabetes. Study Selection: Original studies published in English or Scandinavian languages were included. Studies with a control group were included while studies published as abstracts and case reports were excluded. Data Extraction: The methodological quality, in terms of risk of bias, was assessed by pairs of reviewers. Robins-I (www.methods.cochrane.org) was used for risk of bias assessment in original articles. For systematic reviews, AMSTAR (www.amstar.ca) was used. For certainty of evidence, we used the GRADE system. The systematic review followed PRISMA guidelines. When possible, meta-analyses were performed. Results: The search included 11,767 articles out of which 173 met the inclusion criteria and were included in the qualitative analysis, while 63 were included in quantitative synthesis (meta-analyses). High birth weight and/or LGA was associated with low to moderately elevated risks for certain malignancies in childhood, breast cancer, several psychiatric disorders, hypertension in childhood, and type 1 and 2 diabetes. Conclusions: Although the increased risks for adverse outcome in offspring associated with high birth weight and LGA represent serious health effects in childhood and in adulthood, the size of these effects seems moderate. The identified risk association should, however, be taken into account in decisions concerning fresh and frozen ART cycles and is of general importance in view of the increasing prevalence in high birthweight babies.
Subject: assisted reproduction
frozen embryo transfer
large for gestational age
high birth weight
long-term morbidity
cancer
diabetes
PERINATAL RISK-FACTORS
BREAST-CANCER RISK
ACUTE LYMPHOBLASTIC-LEUKEMIA
DEPENDENT DIABETES-MELLITUS
CENTRAL-NERVOUS-SYSTEM
BODY-MASS INDEX
WILMS-TUMOR
CHILDHOOD LEUKEMIA
GESTATIONAL-AGE
BLOOD-PRESSURE
3123 Gynaecology and paediatrics
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