Psychiatric disorders as risk factors for type 2 diabetes : An umbrella review of systematic reviews with and without meta-analyses

Show full item record



Permalink

http://hdl.handle.net/10138/333940

Citation

Lindekilde , N , Rutters , F , Henriksen , J E , Lasgaard , M , Schram , M T , Rubin , K H , Kivimäki , M , Nefs , G & Pouwer , F 2021 , ' Psychiatric disorders as risk factors for type 2 diabetes : An umbrella review of systematic reviews with and without meta-analyses ' , Diabetes Research and Clinical Practice , vol. 176 , 108855 . https://doi.org/10.1016/j.diabres.2021.108855

Title: Psychiatric disorders as risk factors for type 2 diabetes : An umbrella review of systematic reviews with and without meta-analyses
Author: Lindekilde, Nanna; Rutters, Femke; Henriksen, Jan Erik; Lasgaard, Mathias; Schram, Miranda T.; Rubin, Katrine Hass; Kivimäki, Mika; Nefs, Giesje; Pouwer, Frans
Contributor: University of Helsinki, Clinicum
Date: 2021-06
Language: eng
Number of pages: 14
Belongs to series: Diabetes Research and Clinical Practice
ISSN: 0168-8227
URI: http://hdl.handle.net/10138/333940
Abstract: Having a psychiatric disorder may increase the risk of developing type 2 diabetes[T2D] and this umbrella review aims to determine whether people with a psychiatric disorder have an increased risk of developing T2D and to investigate potential underlying mechanisms. A literature search was performed to identify systematic reviews of longitudinal studies investigating different psychiatric disorders as risk factors for incident T2D in humans (>18 years). A total of 8612 abstracts were identified, 180 full-text articles were read, and 25 systematic reviews were included. Six categories of psychiatric disorders were identified. Except for eating disorders, all psychiatric disorders were associated with increased risk of incident T2D ranging from RR = 1.18 [95% CI 1.12-1.24] to RR = 1.60 [95% CI 1.37-1.88] for depression; from RR = 1.27 [95% CI 1.19-1.35] to OR = 1.50 [95% CI 1.08-2.10] for use of antidepressant medication; from OR = 1.93 [1.37-2.73] to OR = 1.94 [1.34-2.80] for use of antipsychotic medication; from RR = 1.55 [95% CI 1.21-1.99] to RR = 1.74 [95% CI 1.30- 2.34] for insomnia, and finally showed OR = 1.47 [95% CI 1.23-1.75] for anxiety disorders. Plausible underlying mechanisms were discussed, but in most reviews corrections for mechanisms did not explain the association. Notable, only 16% of the systematic reviews had a high methodological quality. (c) 2021 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Subject: Psychiatric disorders
Type 2 diabetes
Umbrella review
Mental illness
Diabetes mellitus
DEPRESSION
PREVALENCE
MELLITUS
PEOPLE
PREDICTORS
MECHANISMS
SYMPTOMS
DISEASES
QUALITY
ADULTS
3121 General medicine, internal medicine and other clinical medicine
3124 Neurology and psychiatry
3142 Public health care science, environmental and occupational health
Rights:


Files in this item

Total number of downloads: Loading...

Files Size Format View
PIIS016882272100214X.pdf 582.8Kb PDF View/Open

This item appears in the following Collection(s)

Show full item record