HIV Replication Is Increased by RNA Methylation METTL3/METTL14/WTAP Complex Activators

Show full item record



Permalink

http://hdl.handle.net/10138/333967

Citation

Selberg , S , Zusinaite , E , Herodes , K , Seli , N , Kankuri , E , Merits , A & Karelson , M 2021 , ' HIV Replication Is Increased by RNA Methylation METTL3/METTL14/WTAP Complex Activators ' , ACS Omega , vol. 6 , no. 24 , pp. 15957-15963 . https://doi.org/10.1021/acsomega.1c01626

Title: HIV Replication Is Increased by RNA Methylation METTL3/METTL14/WTAP Complex Activators
Author: Selberg, Simona; Zusinaite, Eva; Herodes, Koit; Seli, Neinar; Kankuri, Esko; Merits, Andres; Karelson, Mati
Contributor: University of Helsinki, Medicum
Date: 2021-06-22
Language: eng
Number of pages: 7
Belongs to series: ACS Omega
ISSN: 2470-1343
URI: http://hdl.handle.net/10138/333967
Abstract: The N6-methyladenosine (m(6)A) modifications in both viral and host cell RNAs play an important role in HIV-1 virus genome transcription and virus replication. We demonstrate here that activators of the METTL3/METTL14/WTAP RNA methyltransferase complex enhance the production of virus particles in cells harboring HIV-1 provirus. In parallel, the amount of m(6)A residues in the host cell mRNA was increased in the presence of these activator compounds. Importantly, the m(6)A methylation of the HIV-1 RNA was also enhanced significantly (about 18%). The increase of virus replication by the small-molecule activators of the METTL3/METTL14/WTAP complex excludes them as potential anti-HIV-1 drug candidates. However, the compounds may be of large interest as activators for the latent HIV-1 provirus copies deposited in host cells' genome and the subsequent virus eradication by an antiviral compound.
Subject: REVERSE-TRANSCRIPTASE INHIBITORS
IMMUNODEFICIENCY-VIRUS TYPE-1
NUCLEAR-RNA
HEPATITIS-B
M(6)A
N6-METHYLADENOSINE
TRANSLATION
DISCOVERY
BINDING
LATENCY
3111 Biomedicine
Rights:


Files in this item

Total number of downloads: Loading...

Files Size Format View
acsomega.1c01626.pdf 1.512Mb PDF View/Open

This item appears in the following Collection(s)

Show full item record