Relationship Between Prolonged Intraocular Inflammation and Macular Edema After Cataract Surgery

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http://hdl.handle.net/10138/333998

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Aaronson , A , Taipale , C , Achiron , A , Aaltonen , V , Grzybowski , A & Tuuminen , R 2021 , ' Relationship Between Prolonged Intraocular Inflammation and Macular Edema After Cataract Surgery ' , Translational vision science & technology , vol. 10 , no. 7 , 15 . https://doi.org/10.1167/tvst.10.7.15

Title: Relationship Between Prolonged Intraocular Inflammation and Macular Edema After Cataract Surgery
Author: Aaronson, Alexander; Taipale, Claudia; Achiron, Asaf; Aaltonen, Vesa; Grzybowski, Andrzej; Tuuminen, Raimo
Contributor: University of Helsinki, HUS Head and Neck Center
University of Helsinki, Silmäklinikka
University of Helsinki, Clinicum
Date: 2021-06
Language: eng
Number of pages: 9
Belongs to series: Translational vision science & technology
ISSN: 2164-2591
URI: http://hdl.handle.net/10138/333998
Abstract: Purpose: To assess whether aqueous flare is related to an increased risk of pseudophakic cystoid macular edema (PCME) following uneventful cataract surgery in nondiabetic and diabetic patients. Methods: A post hoc analysis of five consecutive randomized clinical trials in the Department of Ophthalmology, Kymenlaakso Central Hospital, Finland. Aqueous flare levels were recorded in 448 eyes of 448 patients before surgery, and after the course of topical anti-inflammatory treatment 28 days and three months after cataract surgery. Results: Aqueous flare increase of = 50%, >= 100%, and >= 200% associated in central subfield macular thickness (CSMT) increase across the groups at 28 days and three months after surgery. Increase of aqueous flare >= 100% compared to those with Conclusions: At 28 days, aqueous flare increase was associated with macular thickening. A 100% cutoff value could potentially be used when studying anti-inflammatory efficacy of different treatment protocols. Flare values exceeding this cutoff value could be considered as an indication for extending anti-inflammatory therapy. Translational relevance: A 100% increase in aqueous flare at 28 days after cataract surgery from baseline predicted macular thickening up to three months postoperatively. Identifying a correlation between increased aqueous flare levels and pseudophakic cystoid macular edema may allow recognition of the most vulnerable patients, development of prophylactic treatment strategies and reduction of the number and severity of postoperative complications.
Subject: aqueous flare
cataract surgery
intraocular inflammation
macular edema
perioperative treatment
pseudophakic cystoid macular edema
AQUEOUS FLARE INTENSITY
ANTERIOR-CHAMBER FLARE
CELL METER
CYTOKINES
PHACOEMULSIFICATION
PILOCARPINE
TROPICAMIDE
PREVENTION
3125 Otorhinolaryngology, ophthalmology
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