Systemic immune response against the oral pathogens Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans is associated with the formation and rupture of intracranial aneurysms

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Hallikainen , J , Pyysalo , M , Keränen , S , Kellokoski , J , Koivisto , T , Suominen , A L , Pussinen , P , Pessi , T & Frosen , J 2021 , ' Systemic immune response against the oral pathogens Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans is associated with the formation and rupture of intracranial aneurysms ' , European Journal of Neurology , vol. 28 , no. 9 , pp. 3089-3099 . https://doi.org/10.1111/ene.14986

Title: Systemic immune response against the oral pathogens Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans is associated with the formation and rupture of intracranial aneurysms
Author: Hallikainen, Joona; Pyysalo, Mikko; Keränen, Sara; Kellokoski, Jari; Koivisto, Timo; Suominen, Anna Liisa; Pussinen, Pirkko; Pessi, Tanja; Frosen, Juhana
Contributor: University of Helsinki, HUS Head and Neck Center
Date: 2021-09
Language: eng
Number of pages: 11
Belongs to series: European Journal of Neurology
ISSN: 1351-5101
URI: http://hdl.handle.net/10138/334007
Abstract: Background and purpose Periodontal infections are associated with the formation and rupture of intracranial aneurysms (IAs). This study investigated the role of two key periodontal pathogens, Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans. Methods Immunoglobulin A (IgA) and IgG antibodies against P. gingivalis and A. actinomycetemcomitans were measured with enzyme immune assay from the serum of 227 IA patients, of whom 64 also underwent clinical oral examination. As a control group, 1096 participants in a cross-sectional health survey, Health 2000, underwent serological studies and oral examination. Logistic regression was used for multivariate analysis. Immunohistochemistry was performed to demonstrate bacteria-derived epitopes in the IA wall. Results Widespread gingivitis and severe periodontitis were more common in IA patients than in controls (2x and 1.5x, respectively). IgA antibodies against P. gingivalis and A. actinomycetemcomitans were 1.5x and 3-3.4x higher, respectively, in both unruptured and ruptured IA patients compared to controls (p
Subject: aneurysms
infections
oral disease
periodontitis
subarachnoid hemorrhage
TREPONEMA-DENTICOLA
SURGICAL-TREATMENT
RISK-FACTORS
PERIODONTITIS
BACTEREMIA
METAANALYSIS
INFECTIONS
PREVALENCE
EMPHASIS
BINDING
3112 Neurosciences
3124 Neurology and psychiatry
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