High incidence of inguinal hernias among patients with congenital abdominal wall defects: a population-based case-control study.

Show simple item record

dc.contributor.author Raitio, Arimatias
dc.contributor.author Kalliokoski, Nelly
dc.contributor.author Syvänen, Johanna
dc.contributor.author Harju, Samuli
dc.contributor.author Tauriainen, Asta
dc.contributor.author Hyvärinen, Anna
dc.contributor.author Gissler, Mika
dc.contributor.author Helenius, Ilkka
dc.contributor.author Sankilampi, Ulla
dc.date.accessioned 2021-09-06T11:51:01Z
dc.date.available 2021-09-06T11:51:01Z
dc.date.issued 2021-08
dc.identifier.citation Raitio , A , Kalliokoski , N , Syvänen , J , Harju , S , Tauriainen , A , Hyvärinen , A , Gissler , M , Helenius , I & Sankilampi , U 2021 , ' High incidence of inguinal hernias among patients with congenital abdominal wall defects: a population-based case-control study. ' , European journal of pediatrics , vol. 180 , no. 8 , 20210274 , pp. 2693-2698 . https://doi.org/10.1007/s00431-021-04172-2
dc.identifier.other PURE: 165505178
dc.identifier.other PURE UUID: 37f6306f-fed7-42cc-bfec-759a0177b17f
dc.identifier.other WOS: 000668214800001
dc.identifier.other ORCID: /0000-0001-5200-3279/work/99542838
dc.identifier.uri http://hdl.handle.net/10138/334009
dc.description.abstract The aim of this nationwide population-based case-control study was to assess the incidence of inguinal hernia (IH) among patients with congenital abdominal wall defects. All infants born with congenital abdominal wall defects between Jan 1, 1998, and Dec 31, 2014, were identified in the Finnish Register of Congenital Malformations. Six controls matched for gestational age, sex, and year of birth were selected for each case in the Medical Birth Register. The Finnish Hospital Discharge Register was searched for relevant diagnosis codes for IH, and hernia incidence was compared between cases and controls. We identified 178 infants with gastroschisis and 150 with omphalocele and selected randomly 1968 matched, healthy controls for comparison. Incidence of IH was significantly higher in gastroschisis girls than in matched controls, relative risk (RR) 7.20 (95% confidence interval [CI] 2.25-23.07). In boys with gastroschisis, no statistically significant difference was observed, RR 1.60 (95% CI 0.75-3.38). Omphalocele was associated with higher risk of IH compared to matched controls, RR 6.46 (95% CI 3.90-10.71), and the risk was equally elevated in male and female patients. Conclusion: Risk of IH is significantly higher among patients with congenital abdominal wall defects than in healthy controls supporting hypothesis that elevated intra-abdominal pressure could prevent natural closure of processus vaginalis. Parents should be informed of this elevated hernia risk to avoid delays in seeking care. We also recommend careful follow-up during the first months of life as most of these hernias are diagnosed early in life. en
dc.format.extent 6
dc.language.iso eng
dc.relation.ispartof European journal of pediatrics
dc.rights cc_by
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject 3126 Surgery, anesthesiology, intensive care, radiology
dc.subject 3123 Gynaecology and paediatrics
dc.subject Exomphalos
dc.subject Gastroschisis
dc.subject Inguinal hernia
dc.subject Omphalocele
dc.subject RISK-FACTORS
dc.subject OMPHALOCELE
dc.subject INFANTS
dc.subject CLOSURE
dc.subject CHILDREN
dc.subject QUALITY
dc.subject SHUNTS
dc.subject RATES
dc.subject BOYS
dc.title High incidence of inguinal hernias among patients with congenital abdominal wall defects: a population-based case-control study. en
dc.type Article
dc.contributor.organization Department of Surgery
dc.contributor.organization HUS Musculoskeletal and Plastic Surgery
dc.contributor.organization University of Helsinki
dc.contributor.organization I kirurgian klinikka (Töölö)
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1007/s00431-021-04172-2
dc.relation.issn 0340-6199
dc.rights.accesslevel openAccess
dc.type.version publishedVersion
dc.type.version submittedVersion

Files in this item

Total number of downloads: Loading...

Files Size Format View
Raitio2021_Arti ... denceOfInguinalHernias.pdf 763.4Kb PDF View/Open
Raitio_Inguinal_Hernia_EJP_2021.docx 87.59Kb Microsoft Word View/Open

This item appears in the following Collection(s)

Show simple item record