Long-term biodiversity intervention shapes health-associated commensal microbiota among urban day-care children

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Roslund , M , Puhakka , R , Nurminen , N , Oikarinen , S , Siter , N , Grönroos , M , Cinek , O , Kramna , L , Jumpponen , A , Laitinen , O , Rajaniemi , J , Hyöty , H & Sinkkonen , A 2021 , ' Long-term biodiversity intervention shapes health-associated commensal microbiota among urban day-care children ' , Environment International , vol. 157 , 106811 . https://doi.org/10.1016/j.envint.2021.106811

Title: Long-term biodiversity intervention shapes health-associated commensal microbiota among urban day-care children
Author: Roslund, Marja; Puhakka, Riikka; Nurminen, Noora; Oikarinen, Sami; Siter, Nathan; Grönroos, Mira; Cinek, Ondrej; Kramna, Lenka; Jumpponen, Ari; Laitinen, Olli; Rajaniemi, Juho; Hyöty, Heikki; Sinkkonen, Aki
Contributor organization: Ecosystems and Environment Research Programme
Helsinki Institute of Sustainability Science (HELSUS)
Nature-Based Solutions
Environmental Sciences
Aki Tapio Sinkkonen / Principal Investigator
Date: 2021-12
Language: eng
Number of pages: 13
Belongs to series: Environment International
ISSN: 0160-4120
DOI: https://doi.org/10.1016/j.envint.2021.106811
URI: http://hdl.handle.net/10138/334051
Abstract: Background: In modern urban environments children have a high incidence of inflammatory disorders, including allergies, asthma, and type 1 diabetes. The underlying cause of these disorders, according to the biodiversity hypothesis, is an imbalance in immune regulation caused by a weak interaction with environmental microbes. In this 2-year study, we analyzed bacterial community shifts in the soil surface in day-care centers and commensal bacteria inhabiting the mouth, skin, and gut of children. We compared two different day-care environments: standard urban day-care centers and intervention day-care centers. Yards in the latter were amended with biodiverse forest floor vegetation and sod at the beginning of the study. Results: Intervention caused a long-standing increase in the relative abundance of nonpathogenic environmental mycobacteria in the surface soils. Treatment-specific shifts became evident in the community composition of Gammaproteobacteria, Negativicutes, and Bacilli, which jointly accounted for almost 40 and 50% of the taxa on the intervention day-care children's skin and in saliva, respectively. In the year-one skin swabs, richness of Alpha-, Beta-, and Gammaproteobacteria was higher, and the relative abundance of potentially pathogenic bacteria, including Haemophilus parainfluenzae, Streptococcus sp., and Veillonella sp., was lower among children in intervention day-care centers compared with children in standard day-care centers. In the gut, the relative abundance of Clostridium sensu stricto decreased, particularly among the intervention children. Conclusions: This study shows that a 2-year biodiversity intervention shapes human commensal microbiota, including taxa that have been associated with immune regulation. Results indicate that intervention enriched commensal microbiota and suppressed the potentially pathogenic bacteria on the skin. We recommend future studies that expand intervention strategies to immune response and eventually the incidence of immune-mediated diseases.
Subject: 3142 Public health care science, environmental and occupational health
SP NOV.
ORAL MICROBIOME
INNATE IMMUNITY
GUT BACTERIA
FOREST SOIL
GEN. NOV.
DIVERSITY
COLONIZATION
COMMUNITY
DISEASE
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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