Psychotropic Medication After Intensive Care Unit-Treated Pediatric Traumatic Brain Injury

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Mikkonen , E D , Skrifvars , M B , Reinikainen , M , Bendel , S , Laitio , R , Hoppu , S , Ala-Kokko , T , Karppinen , A & Raj , R 2020 , ' Psychotropic Medication After Intensive Care Unit-Treated Pediatric Traumatic Brain Injury ' , Pediatric Neurology , vol. 112 , pp. 64-70 .

Title: Psychotropic Medication After Intensive Care Unit-Treated Pediatric Traumatic Brain Injury
Author: Mikkonen, Era D.; Skrifvars, Markus B.; Reinikainen, Matti; Bendel, Stepani; Laitio, Ruut; Hoppu, Sanna; Ala-Kokko, Tero; Karppinen, Atte; Raj, Rahul
Contributor organization: Anestesiologian yksikkö
HUS Perioperative, Intensive Care and Pain Medicine
Helsinki University Hospital Area
University of Helsinki
HUS Emergency Medicine and Services
Department of Diagnostics and Therapeutics
HUS Neurocenter
Neurokirurgian yksikkö
Staff Services
Date: 2020-11
Language: eng
Number of pages: 7
Belongs to series: Pediatric Neurology
ISSN: 0887-8994
Abstract: Background: Our aim was to assess the occurrence and risk factors for psychotropic medication use after pediatric traumatic brain injury treated in the intensive care unit. Methods: We combined data from the Finnish Intensive Care Consortium database, data on reimbursed medications from the Social Insurance Institute, and individual electronic health care data. We analyzed data on children aged five to 17 years treated for traumatic brain injury in intensive care units of four university hospitals in Finland during 2003 to 2013 and being alive six months after injury with no history of psychotropic medication use before traumatic brain injury. Results: We identified 248 patients of whom 46 (19%) were prescribed a new psychotropic medication after traumatic brain injury. In multivariable logistic regression, a higher age associated with a higher probability for use of any psychotropic medication. Subgroup analyses showed that higher age associated with an increased risk of antidepressant and antipsychotic use but with a decreased risk of stimulant use. Apart from age, we found no other clinical, radiological, or treatment-related factors that significantly associated with subsequent use of psychotropics. Psychotropic medication was most common (45%) in children aged 12 to 17 years and had moderate disability at six-month follow-up. Conclusions: One fifth of children treated in the intensive care unit for traumatic brain injury were prescribed a new psychotropic medication during a median follow-up of three years and five months. Psychotropic medication was most common among teenagers with moderate post-traumatic disability. The need and use of psychotropics postinjury seem multifactorial and not related to any traumatic brain injury type. (C) 2020 Elsevier Inc. All rights reserved.
Subject: Child
Traumatic brain injury
Psychoactive agents
Population at risk
Intensive care units
3112 Neurosciences
3124 Neurology and psychiatry
3123 Gynaecology and paediatrics
Peer reviewed: Yes
Rights: cc_by_nc_nd
Usage restriction: openAccess
Self-archived version: acceptedVersion

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