Compounding Parenteral Products in Pediatric Wards—Effect of Environment and Aseptic Technique on Product Sterility

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http://hdl.handle.net/10138/334182

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Virtanen , S , Kapp , K , Rautamo , M M , Lotta , S , Linden-Lahti , C , Cruz , C D & Tammela , P 2021 , ' Compounding Parenteral Products in Pediatric Wards—Effect of Environment and Aseptic Technique on Product Sterility ' , Healthcare , vol. 9 , no. 8 , 1025 . https://doi.org/10.3390/healthcare9081025

Title: Compounding Parenteral Products in Pediatric Wards—Effect of Environment and Aseptic Technique on Product Sterility
Author: Virtanen, Sonja; Kapp, Karmen; Rautamo, Maria M; Lotta, Schepel; Linden-Lahti, Carita; Cruz, Cristina D.; Tammela, Päivi
Contributor: University of Helsinki, Division of Pharmaceutical Biosciences
University of Helsinki, HUS Pharmacy
University of Helsinki, HUS Pharmacy
University of Helsinki, Bioactivity Screening Group
University of Helsinki, Divisions of Faculty of Pharmacy
Date: 2021-08
Language: eng
Number of pages: 11
Belongs to series: Healthcare
ISSN: 2227-9032
URI: http://hdl.handle.net/10138/334182
Abstract: Parenteral products must be compounded using an aseptic technique to ensure sterility of the medicine. We compared the effect of three clinical environments as compounding areas as well as different aseptic techniques on the sterility of the compounded parenteral product. Clinical pharmacists and pediatric nurses compounded 220 samples in total in three clinical environments: a patient room, a medicine room and biological safety cabinet. The study combined four methods: observation, environmental monitoring (settle plates), monitoring of personnel (finger dab plates) and sterility testing (membrane filtration). Of the compounded samples, 99% were sterile and no significant differences emerged between the clinical environments. Based on the settle plates, the biological safety cabinet was the only area that fulfilled the requirements for eliminating microbial contamination. Most of the steps on the observation form for aseptic techniques were followed. All participants disinfected their hands, wore gloves and disinfected the septum of the vial. Non-contaminated finger dab plates were mostly detected after compounding in the biological safety cabinet. Aseptic techniques were followed relatively well in all environments. However, these results emphasize the importance of good aseptic techniques and support the recommendation of compounding parenteral products in biological safety cabinets in clinical environments.
Subject: 317 Pharmacy
3141 Health care science
parenteral products
compounding
aseptic technique
sterility test
pediatrics
patient safety
MICROBIAL-CONTAMINATION
DIETZIA-MARIS
OUTBREAK
RISK
BACTEREMIA
RATES
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