Antileukemic Activity and Molecular Docking Study of a Polyphenolic Extract from Coriander Seeds

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http://hdl.handle.net/10138/334204

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Mechchate , H , Costa de Oliveira , R , Es-safi , I , Vasconcelos Mourao , E M , Bouhrim , M , Kyrylchuk , A , Soares Pontes , G , Bousta , D & Grafov , A 2021 , ' Antileukemic Activity and Molecular Docking Study of a Polyphenolic Extract from Coriander Seeds ' , Pharmaceuticals , vol. 14 , no. 8 , 770 . https://doi.org/10.3390/ph14080770

Title: Antileukemic Activity and Molecular Docking Study of a Polyphenolic Extract from Coriander Seeds
Author: Mechchate, Hamza; Costa de Oliveira, Regiane; Es-safi, Imane; Vasconcelos Mourao, Emmily Myrella; Bouhrim, Mohamed; Kyrylchuk, Andrii; Soares Pontes, Gemilson; Bousta, Dalila; Grafov, Andriy
Contributor: University of Helsinki, Department of Chemistry
Date: 2021-08
Language: eng
Number of pages: 16
Belongs to series: Pharmaceuticals
ISSN: 1424-8247
URI: http://hdl.handle.net/10138/334204
Abstract: Leukemia is a group of hematological neoplastic disorders linked to high mortality rates worldwide, but increasing resistance has led to the therapeutic failure of conventional chemotherapy. This study aimed to evaluate in vitro the antileukemic activity and potential mechanism of action of a polyphenolic extract obtained from the seeds of Coriandrum sativum L. (CSP). A methylthia-zoletetrazolium assay was performed to assess the CSP cytotoxicity on chronic (K562) and acute (HL60) myeloid leukemia cell lines and on normal Vero cell line. CSP toxicity was also evaluated in vivo using the OECD 423 acute toxicity model on Swiss albino mice. The results demonstrated a remarkable antitumoral activity against K562 and HL60 cell lines (IC50 = 16.86 mu M and 11.75 mu M, respectively) although no cytotoxicity was observed for the Vero cells or mice. A silico study was performed on the following receptors that are highly implicated in the development of leukemia: ABL kinase, ABL1, BCL2, and FLT3. The molecular docking demonstrated a high affinity interaction between the principal CSP components and the receptors. Our findings demonstrated that CSP extract has remarkable antileukemic activity, which is mainly mediated by the flavonoids, catechins, and rutin, all of which showed the highest binding affinity for the targeted receptors. This study revealed a promising active compound alternative research-oriented biopharmacists to explore.
Subject: leukemia
Coriandrum sativum L
polyphenols
HL60
K562
Vero cell line
anticancer activity
molecular docking
ABL kinase
ABL1
BCL2
FLT3
acute toxicity
OECD 423
ABL KINASE
IMATINIB
HEALTH
TEA
317 Pharmacy
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