In Vivo and In Vitro Antidiabetic and Anti-Inflammatory Properties of Flax (Linum usitatissimum L.) Seed Polyphenols

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Mechchate , H , Es-safi , I , Conte , R , Hano , C , Amaghnouje , A , Jawhari , F Z , Radouane , N , Bencheikh , N , Grafov , A & Bousta , D 2021 , ' In Vivo and In Vitro Antidiabetic and Anti-Inflammatory Properties of Flax (Linum usitatissimum L.) Seed Polyphenols ' , Nutrients , vol. 13 , no. 8 , 2759 . https://doi.org/10.3390/nu13082759

Title: In Vivo and In Vitro Antidiabetic and Anti-Inflammatory Properties of Flax (Linum usitatissimum L.) Seed Polyphenols
Author: Mechchate, Hamza; Es-safi, Imane; Conte, Raffaele; Hano, Christophe; Amaghnouje, Amal; Jawhari, Fatima Zahra; Radouane, Nabil; Bencheikh, Noureddine; Grafov, Andriy; Bousta, Dalila
Contributor: University of Helsinki, Department of Chemistry
University of Helsinki, Department of Chemistry
University of Helsinki, Department of Chemistry
Date: 2021-08
Language: eng
Number of pages: 13
Belongs to series: Nutrients
ISSN: 2072-6643
URI: http://hdl.handle.net/10138/334205
Abstract: Flaxseed is an oilseed (45-50% oil on a dry-weight basis) crop. Its oil has demonstrated multiple health benefits and industrial applications. The goal of this research was to evaluate the antidiabetic and anti-inflammatory potential of the free polyphenol fraction of flax (Linum usitatissimum L.) seeds (PLU), based on their use in traditional medicine. Mice with alloxan-induced diabetes were used to study the antidiabetic activity of PLU in vivo, with an oral administration of 25 and 50 mg/kg over 28 days. Measurements of body weight and fasting blood glucose (FBG) were carried out weekly, and biochemical parameters were evaluated. An oral glucose tolerance test was also performed. Inhibitory activities of PLU on alpha-amylase and alpha-glucosidase activities were evaluated in vitro. The anti-inflammatory was evaluated in vivo in Wistar rats using the paw edema induction Test by carrageenan, and in vitro using the hemolysis ratio test. PLU administration to diabetic mice during the study period improved their body weight and FBG levels remarkably. In vitro inhibitory activity of digestive enzymes indicated that they may be involved in the proposed mode of action of PLU extract. Qualitative results of PLU revealed the presence of 18 polyphenols. These findings support daily consumption of flaxseed for people with diabetes, and suggest that polyphenols in flaxseed may serve as dietary supplements or novel phytomedicines to treat diabetes and its complications.
Subject: flax
flaxseed
polyphenols extraction
diabetes mellitus
antidiabetic
anti-inflammatory
dyslipidemia
carrageenan-induced edema
hemolysis test
LC-MS
MS
DERIVATIVES
DIGLUCOSIDE
EXTRACT
116 Chemical sciences
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