Low-Dose Doxycycline Treatment Normalizes Levels of Some Salivary Metabolites Associated with Oral Microbiota in Patients with Primary Sjögren’s Syndrome

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dc.contributor.author Herrala, Maria
dc.contributor.author Turunen, Soile
dc.contributor.author Hanhineva, Kati
dc.contributor.author Lehtonen, Marko
dc.contributor.author Mikkonen, Jopi J. W.
dc.contributor.author Seitsalo, Hubertus
dc.contributor.author Lappalainen, Reijo
dc.contributor.author Tjäderhane, Leo
dc.contributor.author Niemelä, Raija K.
dc.contributor.author Salo, Tuula
dc.contributor.author Myllymaa, Sami
dc.contributor.author Kullaa, Arja M.
dc.contributor.author Kärkkäinen, Olli
dc.date.accessioned 2021-09-09T13:40:19Z
dc.date.available 2021-09-09T13:40:19Z
dc.date.issued 2021-09-03
dc.identifier.citation Herrala, M.; Turunen, S.; Hanhineva, K.; Lehtonen, M.; Mikkonen, J.J.W.; Seitsalo, H.; Lappalainen, R.; Tjäderhane, L.; Niemelä, R.K.; Salo, T.; Myllymaa, S.; Kullaa, A.M.; Kärkkäinen, O. Low-Dose Doxycycline Treatment Normalizes Levels of Some Salivary Metabolites Associated with Oral Microbiota in Patients with Primary Sjögren’s Syndrome. Metabolites 2021, 11, 595.
dc.identifier.uri http://hdl.handle.net/10138/334219
dc.description.abstract Saliva is a complex oral fluid, and plays a major role in oral health. Primary Sjögren’s syndrome (pSS), as an autoimmune disease that typically causes hyposalivation. In the present study, salivary metabolites were studied from stimulated saliva samples (<i>n</i> = 15) of female patients with pSS in a group treated with low-dose doxycycline (LDD), saliva samples (<i>n</i> = 10) of non-treated female patients with pSS, and saliva samples (<i>n</i> = 14) of healthy age-matched females as controls. Saliva samples were analyzed with liquid chromatography mass spectrometry (LC-MS) based on the non-targeted metabolomics method. The saliva metabolite profile differed between pSS patients and the healthy control (HC). In the pSS patients, the LDD treatment normalized saliva levels of several metabolites, including tyrosine glutamine dipeptide, phenylalanine isoleucine dipeptide, valine leucine dipeptide, phenylalanine, pantothenic acid (vitamin B5), urocanic acid, and salivary lipid cholesteryl palmitic acid (CE 16:0), to levels seen in the saliva samples of the HC. In conclusion, the data showed that pSS is associated with an altered saliva metabolite profile compared to the HC and that the LLD treatment normalized levels of several metabolites associated with dysbiosis of oral microbiota in pSS patients. The role of the saliva metabolome in pSS pathology needs to be further studied to clarify if saliva metabolite levels can be used to predict or monitor the progress and treatment of pSS.
dc.publisher Multidisciplinary Digital Publishing Institute
dc.title Low-Dose Doxycycline Treatment Normalizes Levels of Some Salivary Metabolites Associated with Oral Microbiota in Patients with Primary Sjögren’s Syndrome
dc.date.updated 2021-09-09T13:40:19Z
dc.type.uri http://purl.org/eprint/entityType/JournalArticle
dc.type.uri http://purl.org/eprint/entityType/Expression
dc.type.uri http://purl.org/eprint/entityType/Expression

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