Evolutionary Relationships of Ljungan Virus Variants Circulating in Multi-Host Systems across Europe

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Rossi , C , Zadra , N , Fevola , C , Ecke , F , Hornfeldt , B , Kallies , R , Kazimirova , M , Magnusson , M , Olsson , G E , Ulrich , R G , Jaaskelainen , A J , Henttonen , H & Hauffe , H C 2021 , ' Evolutionary Relationships of Ljungan Virus Variants Circulating in Multi-Host Systems across Europe ' , Viruses-Basel , vol. 13 , no. 7 , 1317 . https://doi.org/10.3390/v13071317

Title: Evolutionary Relationships of Ljungan Virus Variants Circulating in Multi-Host Systems across Europe
Author: Rossi, Chiara; Zadra, Nicola; Fevola, Cristina; Ecke, Frauke; Hornfeldt, Birger; Kallies, Rene; Kazimirova, Maria; Magnusson, Magnus; Olsson, Gert E.; Ulrich, Rainer G.; Jaaskelainen, Anne J.; Henttonen, Heikki; Hauffe, Heidi C.
Contributor: University of Helsinki, Department of Virology
Date: 2021-07
Language: eng
Number of pages: 18
Belongs to series: Viruses-Basel
ISSN: 1999-4915
URI: http://hdl.handle.net/10138/334316
Abstract: The picornavirus named 'Ljungan virus' (LV, species Parechovirus B) has been detected in a dozen small mammal species from across Europe, but detailed information on its genetic diversity and host specificity is lacking. Here, we analyze the evolutionary relationships of LV variants circulating in free-living mammal populations by comparing the phylogenetics of the VP1 region (encoding the capsid protein and associated with LV serotype) and the 3D(pol) region (encoding the RNA polymerase) from 24 LV RNA-positive animals and a fragment of the 5 ' untranslated region (UTR) sequence (used for defining strains) in sympatric small mammals. We define three new VP1 genotypes: two in bank voles (Myodes glareolus) (genotype 8 from Finland, Sweden, France, and Italy, and genotype 9 from France and Italy) and one in field voles (Microtus arvalis) (genotype 7 from Finland). There are several other indications that LV variants are host-specific, at least in parts of their range. Our results suggest that LV evolution is rapid, ongoing and affected by genetic drift, purifying selection, spillover and host evolutionary history. Although recent studies suggest that LV does not have zoonotic potential, its widespread geographical and host distribution in natural populations of well-characterized small mammals could make it useful as a model for studying RNA virus evolution and transmission.
Subject: Picornaviridae
Parechovirus B
Ljungan virus isolates
small mammals
rodent-borne virus
zoonosis
bank vole
VOLES MYODES-GLAREOLUS
HUMAN PARECHOVIRUSES
LYMPHOCYTIC CHORIOMENINGITIS
MOLECULAR CHARACTERIZATION
MAXIMUM-LIKELIHOOD
SEROLOGICAL SURVEY
MITOCHONDRIAL-DNA
CLINICAL-SAMPLES
PUUMALA VIRUSES
PUBLIC-HEALTH
3111 Biomedicine
11832 Microbiology and virology
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