Voxel and surface based whole brain analysis shows reading skill associated grey matter abnormalities in dyslexia

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Kujala , T , Sihvonen , A , Thiede , A , Palo-oja , P , Virtala , P M , Numminen , J & Laasonen , M 2021 , ' Voxel and surface based whole brain analysis shows reading skill associated grey matter abnormalities in dyslexia ' , Scientific Reports , vol. 11 , no. 1 , 10862 . https://doi.org/10.1038/s41598-021-89317-x

Title: Voxel and surface based whole brain analysis shows reading skill associated grey matter abnormalities in dyslexia
Author: Kujala, Teija; Sihvonen, Aleksi; Thiede, Anja; Palo-oja, Peter; Virtala, Paula Maarit; Numminen, Jussi; Laasonen, Marja
Contributor: University of Helsinki, Mind and Matter
University of Helsinki, Cognitive Brain Research Unit
University of Helsinki, Medicum
University of Helsinki, Department of Psychology and Logopedics
University of Helsinki, Department of Psychology and Logopedics
University of Helsinki, HUS Medical Imaging Center
University of Helsinki, Behavioural Sciences
Date: 2021-05-25
Language: eng
Number of pages: 9
Belongs to series: Scientific Reports
ISSN: 2045-2322
URI: http://hdl.handle.net/10138/334323
Abstract: Developmental dyslexia (DD) is the most prevalent neurodevelopmental disorder with a substantial negative influence on the individual's academic achievement and career. Research on its neuroanatomical origins has continued for half a century, yielding, however, inconsistent results, lowered total brain volume being the most consistent finding. We set out to evaluate the grey matter (GM) volume and cortical abnormalities in adult dyslexic individuals, employing a combination of whole-brain voxel- and surface-based morphometry following current recommendations on analysis approaches, coupled with rigorous neuropsychological testing. Whilst controlling for age, sex, total intracranial volume, and performance IQ, we found both decreased GM volume and cortical thickness in the left insula in participants with DD. Moreover, they had decreased GM volume in left superior temporal gyrus, putamen, globus pallidus, and parahippocampal gyrus. Higher GM volumes and cortical thickness in these areas correlated with better reading and phonological skills, deficits of which are pivotal to DD. Crucially, total brain volume did not influence our results, since it did not differ between the groups. Our findings demonstrating abnormalities in brain areas in individuals with DD, which previously were associated with phonological processing, are compatible with the leading hypotheses on the neurocognitive origins of DD.
Subject: CHILD
CONNECTIVITY
DEFICITS
DEVELOPMENTAL DYSLEXIA
HISTORY
INSULA
METAANALYSIS
MORPHOMETRY
SCALE
VOLUME
6162 Cognitive science
6163 Logopedics
515 Psychology
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