Immunogenomic Landscape of Hematological Malignancies

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Dufva , O , Pölönen , P , Brück , O , Keränen , M A I , Klievink , J , Mehtonen , J , Huuhtanen , J , Kumar , A , Malani , D , Siitonen , S , Kankainen , M , Ghimire , B , Lahtela , J , Mattila , P , Vähä-Koskela , M , Wennerberg , K , Granberg , K , Leivonen , S-K , Meriranta , L , Heckman , C , Leppä , S , Nykter , M , Lohi , O , Heinäniemi , M & Mustjoki , S 2020 , ' Immunogenomic Landscape of Hematological Malignancies ' , Cancer Cell , vol. 38 , no. 3 , pp. 380-399 . https://doi.org/10.1016/j.ccell.2020.06.002

Title: Immunogenomic Landscape of Hematological Malignancies
Author: Dufva, Olli; Pölönen, Petri; Brück, Oscar; Keränen, Mikko A. I.; Klievink, Jay; Mehtonen, Juha; Huuhtanen, Jani; Kumar, Ashwini; Malani, Disha; Siitonen, Sanna; Kankainen, Matti; Ghimire, Bishwa; Lahtela, Jenni; Mattila, Pirkko; Vähä-Koskela, Markus; Wennerberg, Krister; Granberg, Kirsi; Leivonen, Suvi-Katri; Meriranta, Leo; Heckman, Caroline; Leppä, Sirpa; Nykter, Matti; Lohi, Olli; Heinäniemi, Merja; Mustjoki, Satu
Contributor: University of Helsinki, Department of Clinical Chemistry and Hematology
University of Helsinki, Department of Clinical Chemistry and Hematology
University of Helsinki, HUS Comprehensive Cancer Center
University of Helsinki, Department of Oncology
University of Helsinki, Medicum
University of Helsinki, Institute for Molecular Medicine Finland
University of Helsinki, Institute for Molecular Medicine Finland
University of Helsinki, Department of Clinical Chemistry and Hematology
University of Helsinki, HUSLAB
University of Helsinki, Institute for Molecular Medicine Finland
University of Helsinki, Institute for Molecular Medicine Finland
University of Helsinki, Biosciences
University of Helsinki, Institute for Molecular Medicine Finland
University of Helsinki, Krister Wennerberg / Principal Investigator
University of Helsinki, Research Programs Unit
University of Helsinki, Faculty of Medicine
University of Helsinki, Institute for Molecular Medicine Finland
University of Helsinki, Department of Oncology
University of Helsinki, HUS Comprehensive Cancer Center
Date: 2020-09-14
Language: eng
Number of pages: 33
Belongs to series: Cancer Cell
ISSN: 1535-6108
URI: http://hdl.handle.net/10138/334327
Abstract: Understanding factors that shape the immune landscape across hematological malignancies is essential for immunotherapy development. We integrated over 8,000 transcriptomes and 2,000 samples with multilevel genomics of hematological cancers to investigate how immunological features are linked to cancer subtypes, genetic and epigenetic alterations, and patient survival, and validated key findings experimentally. Infiltration of cytotoxic lymphocytes was associated with TP53 and myelodysplasia-related changes in acute myeloid leukemia, and activated B cell-like phenotype and interferon-γ response in lymphoma. CIITA methylation regulating antigen presentation, cancer type-specific immune checkpoints, such as VISTA in myeloid malignancies, and variation in cancer antigen expression further contributed to immune heterogeneity and predicted survival. Our study provides a resource linking immunology with cancer subtypes and genomics in hematological malignancies.
Subject: CANCER-TESTIS ANTIGENS
CLASS-II EXPRESSION
COMPLEX CLASS-II
GENE-EXPRESSION
IMMUNE CELLS
TUMOR MICROENVIRONMENT
MULTIPLE-MYELOMA
INTERFERON-GAMMA
DNA METHYLATION
PD-1 BLOCKADE
3122 Cancers
3111 Biomedicine
1182 Biochemistry, cell and molecular biology
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