Immunogenomic Landscape of Hematological Malignancies

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Dufva , O , Pölönen , P , Brück , O , Keränen , M A I , Klievink , J , Mehtonen , J , Huuhtanen , J , Kumar , A , Malani , D , Siitonen , S , Kankainen , M , Ghimire , B , Lahtela , J , Mattila , P , Vähä-Koskela , M , Wennerberg , K , Granberg , K , Leivonen , S-K , Meriranta , L , Heckman , C , Leppä , S , Nykter , M , Lohi , O , Heinäniemi , M & Mustjoki , S 2020 , ' Immunogenomic Landscape of Hematological Malignancies ' , Cancer Cell , vol. 38 , no. 3 , pp. 380-399 . https://doi.org/10.1016/j.ccell.2020.06.002

Title: Immunogenomic Landscape of Hematological Malignancies
Author: Dufva, Olli; Pölönen, Petri; Brück, Oscar; Keränen, Mikko A. I.; Klievink, Jay; Mehtonen, Juha; Huuhtanen, Jani; Kumar, Ashwini; Malani, Disha; Siitonen, Sanna; Kankainen, Matti; Ghimire, Bishwa; Lahtela, Jenni; Mattila, Pirkko; Vähä-Koskela, Markus; Wennerberg, Krister; Granberg, Kirsi; Leivonen, Suvi-Katri; Meriranta, Leo; Heckman, Caroline; Leppä, Sirpa; Nykter, Matti; Lohi, Olli; Heinäniemi, Merja; Mustjoki, Satu
Contributor organization: Department of Clinical Chemistry and Hematology
HUS Comprehensive Cancer Center
Department of Oncology
Hematologian yksikkö
TRIMM - Translational Immunology Research Program
Research Programs Unit
Digital Precision Cancer Medicine (iCAN)
Medicum
Institute for Molecular Medicine Finland
Precision Systems Medicine
HUSLAB
Biosciences
Krister Wennerberg / Principal Investigator
ATG - Applied Tumor Genomics
Faculty of Medicine
Helsinki University Hospital Area
Clinicum
Date: 2020-09-14
Language: eng
Number of pages: 33
Belongs to series: Cancer Cell
ISSN: 1535-6108
DOI: https://doi.org/10.1016/j.ccell.2020.06.002
URI: http://hdl.handle.net/10138/334327
Abstract: Understanding factors that shape the immune landscape across hematological malignancies is essential for immunotherapy development. We integrated over 8,000 transcriptomes and 2,000 samples with multilevel genomics of hematological cancers to investigate how immunological features are linked to cancer subtypes, genetic and epigenetic alterations, and patient survival, and validated key findings experimentally. Infiltration of cytotoxic lymphocytes was associated with TP53 and myelodysplasia-related changes in acute myeloid leukemia, and activated B cell-like phenotype and interferon-γ response in lymphoma. CIITA methylation regulating antigen presentation, cancer type-specific immune checkpoints, such as VISTA in myeloid malignancies, and variation in cancer antigen expression further contributed to immune heterogeneity and predicted survival. Our study provides a resource linking immunology with cancer subtypes and genomics in hematological malignancies.
Subject: CANCER-TESTIS ANTIGENS
CLASS-II EXPRESSION
COMPLEX CLASS-II
GENE-EXPRESSION
IMMUNE CELLS
TUMOR MICROENVIRONMENT
MULTIPLE-MYELOMA
INTERFERON-GAMMA
DNA METHYLATION
PD-1 BLOCKADE
3122 Cancers
3111 Biomedicine
1182 Biochemistry, cell and molecular biology
Peer reviewed: Yes
Rights: cc_by_nc_nd
Usage restriction: openAccess
Self-archived version: draft


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