Immunogenomic Landscape of Hematological Malignancies
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Dufva , O , Pölönen , P , Brück , O , Keränen , M A I , Klievink , J , Mehtonen , J , Huuhtanen , J , Kumar , A , Malani , D , Siitonen , S , Kankainen , M , Ghimire , B , Lahtela , J , Mattila , P , Vähä-Koskela , M , Wennerberg , K , Granberg , K , Leivonen , S-K , Meriranta , L , Heckman , C , Leppä , S , Nykter , M , Lohi , O , Heinäniemi , M & Mustjoki , S 2020 , ' Immunogenomic Landscape of Hematological Malignancies ' , Cancer Cell , vol. 38 , no. 3 , pp. 380-399 . https://doi.org/10.1016/j.ccell.2020.06.002
| Title: | Immunogenomic Landscape of Hematological Malignancies |
| Author: | Dufva, Olli; Pölönen, Petri; Brück, Oscar; Keränen, Mikko A. I.; Klievink, Jay; Mehtonen, Juha; Huuhtanen, Jani; Kumar, Ashwini; Malani, Disha; Siitonen, Sanna; Kankainen, Matti; Ghimire, Bishwa; Lahtela, Jenni; Mattila, Pirkko; Vähä-Koskela, Markus; Wennerberg, Krister; Granberg, Kirsi; Leivonen, Suvi-Katri; Meriranta, Leo; Heckman, Caroline; Leppä, Sirpa; Nykter, Matti; Lohi, Olli; Heinäniemi, Merja; Mustjoki, Satu |
| Contributor: | University of Helsinki, Department of Clinical Chemistry and Hematology University of Helsinki, Department of Clinical Chemistry and Hematology University of Helsinki, HUS Comprehensive Cancer Center University of Helsinki, Department of Oncology University of Helsinki, Medicum University of Helsinki, Institute for Molecular Medicine Finland University of Helsinki, Institute for Molecular Medicine Finland University of Helsinki, Department of Clinical Chemistry and Hematology University of Helsinki, HUSLAB University of Helsinki, Institute for Molecular Medicine Finland University of Helsinki, Institute for Molecular Medicine Finland University of Helsinki, Biosciences University of Helsinki, Institute for Molecular Medicine Finland University of Helsinki, Krister Wennerberg / Principal Investigator University of Helsinki, Research Programs Unit University of Helsinki, Faculty of Medicine University of Helsinki, Institute for Molecular Medicine Finland University of Helsinki, Department of Oncology University of Helsinki, HUS Comprehensive Cancer Center |
| Date: | 2020-09-14 |
| Language: | eng |
| Number of pages: | 33 |
| Belongs to series: | Cancer Cell |
| ISSN: | 1535-6108 |
| URI: | http://hdl.handle.net/10138/334327 |
| Abstract: | Understanding factors that shape the immune landscape across hematological malignancies is essential for immunotherapy development. We integrated over 8,000 transcriptomes and 2,000 samples with multilevel genomics of hematological cancers to investigate how immunological features are linked to cancer subtypes, genetic and epigenetic alterations, and patient survival, and validated key findings experimentally. Infiltration of cytotoxic lymphocytes was associated with TP53 and myelodysplasia-related changes in acute myeloid leukemia, and activated B cell-like phenotype and interferon-γ response in lymphoma. CIITA methylation regulating antigen presentation, cancer type-specific immune checkpoints, such as VISTA in myeloid malignancies, and variation in cancer antigen expression further contributed to immune heterogeneity and predicted survival. Our study provides a resource linking immunology with cancer subtypes and genomics in hematological malignancies. |
| Subject: |
CANCER-TESTIS ANTIGENS
CLASS-II EXPRESSION COMPLEX CLASS-II GENE-EXPRESSION IMMUNE CELLS TUMOR MICROENVIRONMENT MULTIPLE-MYELOMA INTERFERON-GAMMA DNA METHYLATION PD-1 BLOCKADE 3122 Cancers 3111 Biomedicine 1182 Biochemistry, cell and molecular biology |
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Articles from TUHAT CRIS [38602]