Immunogenomic Landscape of Hematological Malignancies
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Dufva , O , Pölönen , P , Brück , O , Keränen , M A I , Klievink , J , Mehtonen , J , Huuhtanen , J , Kumar , A , Malani , D , Siitonen , S , Kankainen , M , Ghimire , B , Lahtela , J , Mattila , P , Vähä-Koskela , M , Wennerberg , K , Granberg , K , Leivonen , S-K , Meriranta , L , Heckman , C , Leppä , S , Nykter , M , Lohi , O , Heinäniemi , M & Mustjoki , S 2020 , ' Immunogenomic Landscape of Hematological Malignancies ' , Cancer Cell , vol. 38 , no. 3 , pp. 380-399 . https://doi.org/10.1016/j.ccell.2020.06.002
| Title: | Immunogenomic Landscape of Hematological Malignancies |
| Author: | Dufva, Olli; Pölönen, Petri; Brück, Oscar; Keränen, Mikko A. I.; Klievink, Jay; Mehtonen, Juha; Huuhtanen, Jani; Kumar, Ashwini; Malani, Disha; Siitonen, Sanna; Kankainen, Matti; Ghimire, Bishwa; Lahtela, Jenni; Mattila, Pirkko; Vähä-Koskela, Markus; Wennerberg, Krister; Granberg, Kirsi; Leivonen, Suvi-Katri; Meriranta, Leo; Heckman, Caroline; Leppä, Sirpa; Nykter, Matti; Lohi, Olli; Heinäniemi, Merja; Mustjoki, Satu |
| Contributor organization: | Department of Clinical Chemistry and Hematology HUS Comprehensive Cancer Center Department of Oncology Hematologian yksikkö TRIMM - Translational Immunology Research Program Research Programs Unit Digital Precision Cancer Medicine (iCAN) Medicum Institute for Molecular Medicine Finland Precision Systems Medicine HUSLAB Biosciences Krister Wennerberg / Principal Investigator ATG - Applied Tumor Genomics Faculty of Medicine Helsinki University Hospital Area Clinicum |
| Date: | 2020-09-14 |
| Language: | eng |
| Number of pages: | 33 |
| Belongs to series: | Cancer Cell |
| ISSN: | 1535-6108 |
| DOI: | https://doi.org/10.1016/j.ccell.2020.06.002 |
| URI: | http://hdl.handle.net/10138/334327 |
| Abstract: | Understanding factors that shape the immune landscape across hematological malignancies is essential for immunotherapy development. We integrated over 8,000 transcriptomes and 2,000 samples with multilevel genomics of hematological cancers to investigate how immunological features are linked to cancer subtypes, genetic and epigenetic alterations, and patient survival, and validated key findings experimentally. Infiltration of cytotoxic lymphocytes was associated with TP53 and myelodysplasia-related changes in acute myeloid leukemia, and activated B cell-like phenotype and interferon-γ response in lymphoma. CIITA methylation regulating antigen presentation, cancer type-specific immune checkpoints, such as VISTA in myeloid malignancies, and variation in cancer antigen expression further contributed to immune heterogeneity and predicted survival. Our study provides a resource linking immunology with cancer subtypes and genomics in hematological malignancies. |
| Subject: |
CANCER-TESTIS ANTIGENS
CLASS-II EXPRESSION COMPLEX CLASS-II GENE-EXPRESSION IMMUNE CELLS TUMOR MICROENVIRONMENT MULTIPLE-MYELOMA INTERFERON-GAMMA DNA METHYLATION PD-1 BLOCKADE 3122 Cancers 3111 Biomedicine 1182 Biochemistry, cell and molecular biology |
| Peer reviewed: | Yes |
| Rights: | cc_by_nc_nd |
| Usage restriction: | openAccess |
| Self-archived version: | draft |
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Articles from TUHAT CRIS [46481]