Scoring of Growth of Unruptured Intracranial Aneurysms

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Juvela , S 2020 , ' Scoring of Growth of Unruptured Intracranial Aneurysms ' , Journal of clinical medicine , vol. 9 , no. 10 , 3339 .

Title: Scoring of Growth of Unruptured Intracranial Aneurysms
Author: Juvela, Seppo
Contributor: University of Helsinki, HUS Neurocenter
Date: 2020-10-18
Language: eng
Number of pages: 10
Belongs to series: Journal of clinical medicine
ISSN: 2077-0383
Abstract: The purpose was to obtain a reliable scoring for growth of unruptured intracranial aneurysms (UIAs) in a long-term follow-up study from variables known at baseline and to compare it with the ELAPSS (Earlier subarachnoid hemorrhage, Location of the aneurysm, Age > 60 years, Population, Size of the aneurysm, and Shape of the aneurysm) score obtained froman individual-based meta-analysis. The series consists of 87 patients with 111 UIAs and 1669 person-years of follow-up between aneurysm size measurements (median follow-up time per patient 21.7, range 1.2 to 51.0 years). These were initially diagnosed between 1956 and 1978, when UIAs were not treated in our country. ELAPSS scores at baseline did not dier between those with and those without aneurysm growth. The area under the curve (AUC) for the receiver operating curve (ROC) of the ELAPSS score for predicting long-term growth was fail (0.474, 95% CI 0.345–0.603), and the optimal cut-o point was obtained at 7 vs. <7 points for sensitivity (0.829) and specificity (0.217). In the present series UIA growth was best predicted by female sex (4 points), smoking at baseline (3 points), and age <40 years (2 points). The AUC for the ROC of the new scoring was fair (0.662, 95% CI 0.546–0.779), which was significantly better than that of ELAPSS score (p < 0.05). The optimal cut-o point was obtained at 4 vs. <4 points for sensitivity (0.971) and specificity (0.304). A new simple scoring consisting of only female sex, cigarette smoking and age <40 years predicted growth of an intracranial aneurysm in long-term follow-up, significantly better than the ELAPSS score.
Subject: unruptured intracranial aneurysm
natural history
cigarette smoking
risk factors
aneurysm growth
subarachnoid hemorrhage
3124 Neurology and psychiatry
IIntracranial aneurysm
Subarachnoid hemorrhage
Aneurysm growth
Cigarette smoking
Female sex
Aneurysm location
Aneurysm size
3126 Surgery, anesthesiology, intensive care, radiology
aneurysm rupture

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