Geographical Distribution and Genetic Diversity of Bank Vole Hepaciviruses in Europe

Show simple item record Schneider, Julia Hoffmann, Bernd Fevola, Cristina Schmidt, Marie Luisa Imholt, Christian Fischer, Stefan Ecke, Frauke Hoernfeldt, Birger Magnusson, Magnus Olsson, Gert E. Rizzoli, Annapaola Tagliapietra, Valentina Chiari, Mario Reusken, Chantal Buzan, Elena Kazimirova, Maria Stanko, Michal White, Thomas A. Reil, Daniela Obiegala, Anna Meredith, Anna Drexler, Jan Felix Essbauer, Sandra Henttonen, Heikki Jacob, Jens Hauffe, Heidi C. Beer, Martin Heckel, Gerald Ulrich, Rainer G. 2021-09-14T12:09:01Z 2021-09-14T12:09:01Z 2021-07
dc.identifier.citation Schneider , J , Hoffmann , B , Fevola , C , Schmidt , M L , Imholt , C , Fischer , S , Ecke , F , Hoernfeldt , B , Magnusson , M , Olsson , G E , Rizzoli , A , Tagliapietra , V , Chiari , M , Reusken , C , Buzan , E , Kazimirova , M , Stanko , M , White , T A , Reil , D , Obiegala , A , Meredith , A , Drexler , J F , Essbauer , S , Henttonen , H , Jacob , J , Hauffe , H C , Beer , M , Heckel , G & Ulrich , R G 2021 , ' Geographical Distribution and Genetic Diversity of Bank Vole Hepaciviruses in Europe ' , Viruses (Basel) , vol. 13 , no. 7 , 1258 .
dc.identifier.other PURE: 168452395
dc.identifier.other PURE UUID: 241ed076-5b0e-4311-be5b-0f6826ff687e
dc.identifier.other WOS: 000677079300001
dc.description.abstract The development of new diagnostic methods resulted in the discovery of novel hepaciviruses in wild populations of the bank vole (Myodes glareolus, syn. Clethrionomys glareolus). The naturally infected voles demonstrate signs of hepatitis similar to those induced by hepatitis C virus (HCV) in humans. The aim of the present research was to investigate the geographical distribution of bank vole-associated hepaciviruses (BvHVs) and their genetic diversity in Europe. Real-time reverse transcription polymerase chain reaction (RT-qPCR) screening revealed BvHV RNA in 442 out of 1838 (24.0%) bank voles from nine European countries and in one of seven northern red-backed voles (Myodes rutilus, syn. Clethrionomys rutilus). BvHV RNA was not found in any other small mammal species (n = 23) tested here. Phylogenetic and isolation-by-distance analyses confirmed the occurrence of both BvHV species (Hepacivirus F and Hepacivirus J) and their sympatric occurrence at several trapping sites in two countries. The broad geographical distribution of BvHVs across Europe was associated with their presence in bank voles of different evolutionary lineages. The extensive geographical distribution and high levels of genetic diversity of BvHVs, as well as the high population fluctuations of bank voles and occasional commensalism in some parts of Europe warrant future studies on the zoonotic potential of BvHVs. en
dc.format.extent 14
dc.language.iso eng
dc.relation.ispartof Viruses (Basel)
dc.rights cc_by
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject bank vole hepaciviruses
dc.subject HCV
dc.subject Hepacivirus F
dc.subject Hepacivirus J
dc.subject rodent-borne pathogen
dc.subject Europe
dc.subject emerging virus
dc.subject HOST
dc.subject 3111 Biomedicine
dc.subject 11832 Microbiology and virology
dc.title Geographical Distribution and Genetic Diversity of Bank Vole Hepaciviruses in Europe en
dc.type Article
dc.contributor.organization Department of Virology
dc.contributor.organization Faculty of Medicine
dc.contributor.organization University of Helsinki
dc.description.reviewstatus Peer reviewed
dc.relation.issn 1999-4915
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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