Bacterial infections as novel risk factors of severe diabetic retinopathy in individuals with type 1 diabetes

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Simonsen , J R , Järvinen , A , Hietala , K , Harjutsalo , V , Forsblom , C , Groop , P-H & Lehto , M 2021 , ' Bacterial infections as novel risk factors of severe diabetic retinopathy in individuals with type 1 diabetes ' , British Journal of Ophthalmology , vol. 105 , no. 8 , pp. 1104-1110 . https://doi.org/10.1136/bjophthalmol-2020-316202

Title: Bacterial infections as novel risk factors of severe diabetic retinopathy in individuals with type 1 diabetes
Author: Simonsen, Johan Rasmus; Järvinen, Asko; Hietala, Kustaa; Harjutsalo, Valma; Forsblom, Carol; Groop, Per-Henrik; Lehto, Markku
Contributor: University of Helsinki, HUS Abdominal Center
University of Helsinki, HUS Inflammation Center
University of Helsinki, Folkhälsan Research Center
University of Helsinki, Nefrologian yksikkö
University of Helsinki, Research Programs Unit
University of Helsinki, HUS Abdominal Center
Date: 2021-08
Language: eng
Number of pages: 7
Belongs to series: British Journal of Ophthalmology
ISSN: 0007-1161
URI: http://hdl.handle.net/10138/334368
Abstract: Background/Aims Diabetic retinopathy (DR) is associated and shares many risk factors with other diabetic complications, including inflammation. Bacterial infections, potent inducers of inflammation have been associated with the development of diabetic complications apart from DR. Our aim was to investigate the association between bacterial infections and DR. Methods Adult individuals with type 1 diabetes (n=1043) were recruited from the Finnish Diabetic Nephropathy Study (FinnDiane), a prospective follow-up study. DR was defined as incident severe diabetic retinopathy (SDR), identified as first laser treatment. Data on DR were obtained through fundus photographs and medical records, data on bacterial infections from comprehensive national registries (1 January 1995 to 31 December 2015). Risk factors for DR and serum bacterial lipopolysaccharide (LPS) activity were determined at baseline. Results Individuals with incident SDR (n=413) had a higher mean number of antibiotic purchases/follow-up year compared with individuals without incident SDR (n=630) (0.92 [95% CI 0.82 to 1.02] vs 0.67 [0.62-0.73], p=0.02), as well as higher levels of LPS activity (0.61 [0.58-0.65] vs 0.56 [0.54-0.59] EU/mL, p=0.03). Individuals with on average >= 1 purchase per follow-up year (n=269) had 1.5 times higher cumulative incidence of SDR, compared with individuals with
Subject: Epidemiology
Infection
Inflammation
Treatment Lasers
CHRONIC KIDNEY-DISEASE
RENAL-INSUFFICIENCY
ATHEROSCLEROSIS
LEUKOSTASIS
ASSOCIATION
MORTALITY
ADHESION
3125 Otorhinolaryngology, ophthalmology
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