Presence of high-risk HLA genotype is the most important individual risk factor for coeliac disease among at-risk relatives

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dc.contributor.author Paavola, Saana
dc.contributor.author Lindfors, Katri
dc.contributor.author Kivelä, Laura
dc.contributor.author Cerqueira, Juliana
dc.contributor.author Huhtala, Heini
dc.contributor.author Saavalainen, Päivi
dc.contributor.author Tauschi, Riku
dc.contributor.author Kaukinen, Katri
dc.contributor.author Kurppa, Kalle
dc.date.accessioned 2021-09-20T05:20:01Z
dc.date.available 2021-09-20T05:20:01Z
dc.date.issued 2021-09
dc.identifier.citation Paavola , S , Lindfors , K , Kivelä , L , Cerqueira , J , Huhtala , H , Saavalainen , P , Tauschi , R , Kaukinen , K & Kurppa , K 2021 , ' Presence of high-risk HLA genotype is the most important individual risk factor for coeliac disease among at-risk relatives ' , Alimentary Pharmacology & Therapeutics , vol. 54 , no. 6 , pp. 805-813 . https://doi.org/10.1111/apt.16534
dc.identifier.other PURE: 168605356
dc.identifier.other PURE UUID: 62544001-1a35-4f09-a064-6bbe7f658f96
dc.identifier.other WOS: 000674215600001
dc.identifier.uri http://hdl.handle.net/10138/334449
dc.description.abstract Background Family screening has been advocated as a means to reduce the major underdiagnosis of coeliac disease. However, the precise risk of the disease in relatives and the impact of patient- and relative-related individual factors remain obscure. Aims To investigate the individual risk of coeliac disease among patients' relatives. Methods Altogether 2943 relatives of 624 index patients were assessed for the presence of previous coeliac disease diagnosis, or were screened for the disease. Coeliac disease-associated human leucocyte antigen (HLA) genotype was determined from all participants. The association between individual factors and new screening positivity was assessed by logistic regression. Results There were 229 previously diagnosed non-index relatives with coeliac disease and 2714 non-affected (2067 first-degree, 647 more distant) relatives. Of these 2714 relatives, 129 (4.8%) were screening-positive (first-degree 5.1%, second-degree 3.6%, more distant 3.5%). The combined prevalence of the previously diagnosed and now detected cases in relatives was 12.2% (6.3% clinically detected, 5.9% screen-detected). In univariate analysis, age en
dc.format.extent 9
dc.language.iso eng
dc.relation.ispartof Alimentary Pharmacology & Therapeutics
dc.rights cc_by_nc_nd
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject PEDIATRIC GASTROENTEROLOGY
dc.subject UNITED-STATES
dc.subject PREVALENCE
dc.subject POPULATION
dc.subject DIAGNOSIS
dc.subject SYMPTOMS
dc.subject SEROLOGY
dc.subject CHILDREN
dc.subject GUIDELINES
dc.subject ANTIBODIES
dc.subject 3121 General medicine, internal medicine and other clinical medicine
dc.subject 317 Pharmacy
dc.title Presence of high-risk HLA genotype is the most important individual risk factor for coeliac disease among at-risk relatives en
dc.type Article
dc.contributor.organization TRIMM - Translational Immunology Research Program
dc.contributor.organization Immunomics
dc.contributor.organization Department of Medical and Clinical Genetics
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1111/apt.16534
dc.relation.issn 0269-2813
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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