Asthma Remission by Age at Diagnosis and Gender in a Population-Based Study

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Honkamäki , J , Piirilä , P , Hisinger-Mölkänen , H , Tuomisto , L E , Andersen , H , Huhtala , H , Sovijärvi , A , Lindqvist , A , Backman , H , Lundbäck , B , Rönmark , E , Lehtimäki , L , Pallasaho , P , Ilmarinen , P & Kankaanranta , H 2021 , ' Asthma Remission by Age at Diagnosis and Gender in a Population-Based Study ' , Journal of allergy and clinical immunology: In practice , vol. 9 , no. 5 , pp. 1950-+ .

Title: Asthma Remission by Age at Diagnosis and Gender in a Population-Based Study
Author: Honkamäki, Jasmin; Piirilä, Päivi; Hisinger-Mölkänen, Hanna; Tuomisto, Leena E.; Andersen, Heidi; Huhtala, Heini; Sovijärvi, Anssi; Lindqvist, Ari; Backman, Helena; Lundbäck, Bo; Rönmark, Eva; Lehtimäki, Lauri; Pallasaho, Paula; Ilmarinen, Pinja; Kankaanranta, Hannu
Contributor organization: HUS Medical Imaging Center
Department of Diagnostics and Therapeutics
University of Helsinki
Faculty of Medicine
HUS Heart and Lung Center
Department of Medicine
Keuhkosairauksien yksikkö
Date: 2021-05
Language: eng
Number of pages: 14
Belongs to series: Journal of allergy and clinical immunology: In practice
ISSN: 2213-2198
Abstract: BACKGROUND: Child-onset asthma is known to remit with high probability, but remission in adult-onset asthma is seem-ingly less frequent. Reports of the association between remission and asthma age of onset up to late adulthood are scarce. OBJECTIVE: To evaluate the association between asthma remission, age at diagnosis and gender, and assess risk factors of nonremission. METHODS: In 2016, a random sample of 16,000 subjects aged 20 to 69 years from Helsinki and Western Finland were sent a FinEsS questionnaire. Physician-diagnosed asthma was catego-rized by age at diagnosis to early-(0-11 years), intermediate-(12-39 years), and late-diagnosed (40-69 years) asthma. Asthma remission was defined by not having had asthma symptoms and not having used asthma medication in the past 12 months. RESULTS: Totally, 8199 (51.5%) responded, and 879 reported physician-diagnosed asthma. Remission was most common in early-diagnosed (30.2%), followed by intermediate-diagnosed (17.9%), and least common in late-diagnosed asthma (5.0%) (P < .001), and the median times from diagnosis were 27, 18.5, and 10 years, respectively. In males, the corresponding remission rates were 36.7%, 20.0%, and 3.4%, and in females, 20.4%, 16.6%, and 5.9% (gender difference P < .001). In multivariable binary logistic regression analysis, signifi-cant risk factors of asthma nonremission were intermediate (odds ratio [OR] = 2.15, 95% confidence interval: 1.373.36) and late diagnosis (OR = 11.06, 4.82-25.37) compared with early diagnosis, chronic obstructive pulmonary disease (COPD) (OR = 5.56, 1.26-24.49), allergic rhinitis (OR = 2.28, 1.50-3.46), and family history of asthma (OR = 1.86, 1.22-2.85). Results were similar after excluding COPD. CONCLUSION: Remission was rare in adults diagnosed with asthma after age 40 years in both genders. Late-diagnosed asthma was the most significant independent risk factor for nonremission. (C) 2020 American Academy of Allergy, Asthma & Immunology
Subject: Asthma
Age of onset
Population study
3121 General medicine, internal medicine and other clinical medicine
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion

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