Asthma Remission by Age at Diagnosis and Gender in a Population-Based Study

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dc.contributor.author Honkamäki, Jasmin
dc.contributor.author Piirilä, Päivi
dc.contributor.author Hisinger-Mölkänen, Hanna
dc.contributor.author Tuomisto, Leena E.
dc.contributor.author Andersen, Heidi
dc.contributor.author Huhtala, Heini
dc.contributor.author Sovijärvi, Anssi
dc.contributor.author Lindqvist, Ari
dc.contributor.author Backman, Helena
dc.contributor.author Lundbäck, Bo
dc.contributor.author Rönmark, Eva
dc.contributor.author Lehtimäki, Lauri
dc.contributor.author Pallasaho, Paula
dc.contributor.author Ilmarinen, Pinja
dc.contributor.author Kankaanranta, Hannu
dc.date.accessioned 2021-09-20T06:45:01Z
dc.date.available 2021-09-20T06:45:01Z
dc.date.issued 2021-05
dc.identifier.citation Honkamäki , J , Piirilä , P , Hisinger-Mölkänen , H , Tuomisto , L E , Andersen , H , Huhtala , H , Sovijärvi , A , Lindqvist , A , Backman , H , Lundbäck , B , Rönmark , E , Lehtimäki , L , Pallasaho , P , Ilmarinen , P & Kankaanranta , H 2021 , ' Asthma Remission by Age at Diagnosis and Gender in a Population-Based Study ' , Journal of allergy and clinical immunology: In practice , vol. 9 , no. 5 , pp. 1950-+ . https://doi.org/10.1016/j.jaip.2020.12.015
dc.identifier.other PURE: 168607669
dc.identifier.other PURE UUID: 0808af3e-f85c-4f32-9780-7b3ff3804f9c
dc.identifier.other WOS: 000672603600022
dc.identifier.other ORCID: /0000-0002-2535-4409/work/100258416
dc.identifier.uri http://hdl.handle.net/10138/334452
dc.description.abstract BACKGROUND: Child-onset asthma is known to remit with high probability, but remission in adult-onset asthma is seem-ingly less frequent. Reports of the association between remission and asthma age of onset up to late adulthood are scarce. OBJECTIVE: To evaluate the association between asthma remission, age at diagnosis and gender, and assess risk factors of nonremission. METHODS: In 2016, a random sample of 16,000 subjects aged 20 to 69 years from Helsinki and Western Finland were sent a FinEsS questionnaire. Physician-diagnosed asthma was catego-rized by age at diagnosis to early-(0-11 years), intermediate-(12-39 years), and late-diagnosed (40-69 years) asthma. Asthma remission was defined by not having had asthma symptoms and not having used asthma medication in the past 12 months. RESULTS: Totally, 8199 (51.5%) responded, and 879 reported physician-diagnosed asthma. Remission was most common in early-diagnosed (30.2%), followed by intermediate-diagnosed (17.9%), and least common in late-diagnosed asthma (5.0%) (P < .001), and the median times from diagnosis were 27, 18.5, and 10 years, respectively. In males, the corresponding remission rates were 36.7%, 20.0%, and 3.4%, and in females, 20.4%, 16.6%, and 5.9% (gender difference P < .001). In multivariable binary logistic regression analysis, signifi-cant risk factors of asthma nonremission were intermediate (odds ratio [OR] = 2.15, 95% confidence interval: 1.373.36) and late diagnosis (OR = 11.06, 4.82-25.37) compared with early diagnosis, chronic obstructive pulmonary disease (COPD) (OR = 5.56, 1.26-24.49), allergic rhinitis (OR = 2.28, 1.50-3.46), and family history of asthma (OR = 1.86, 1.22-2.85). Results were similar after excluding COPD. CONCLUSION: Remission was rare in adults diagnosed with asthma after age 40 years in both genders. Late-diagnosed asthma was the most significant independent risk factor for nonremission. (C) 2020 American Academy of Allergy, Asthma & Immunology en
dc.format.extent 14
dc.language.iso eng
dc.relation.ispartof Journal of allergy and clinical immunology: In practice
dc.rights cc_by
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject Asthma
dc.subject Remission
dc.subject Gender
dc.subject Age of onset
dc.subject Late-onset
dc.subject Early-onset
dc.subject Adult
dc.subject Population study
dc.subject ADULT-ONSET ASTHMA
dc.subject OBSTRUCTIVE LUNG-DISEASE
dc.subject CHILDHOOD ASTHMA
dc.subject NATURAL-HISTORY
dc.subject SEVERITY
dc.subject PERSISTENCE
dc.subject PREDICTORS
dc.subject PROGNOSIS
dc.subject INCREASE
dc.subject PHENOTYPES
dc.subject 3121 General medicine, internal medicine and other clinical medicine
dc.title Asthma Remission by Age at Diagnosis and Gender in a Population-Based Study en
dc.type Article
dc.contributor.organization HUS Medical Imaging Center
dc.contributor.organization Department of Diagnostics and Therapeutics
dc.contributor.organization Clinicum
dc.contributor.organization University of Helsinki
dc.contributor.organization Faculty of Medicine
dc.contributor.organization HUS Heart and Lung Center
dc.contributor.organization Department of Medicine
dc.contributor.organization Keuhkosairauksien yksikkö
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1016/j.jaip.2020.12.015
dc.relation.issn 2213-2198
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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