Novel personalized cancer vaccine platform based on Bacillus Calmette-Guerin

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dc.contributor.author Ylösmäki, Erkko
dc.contributor.author Fusciello, Manlio
dc.contributor.author Martins, Beatriz
dc.contributor.author Feola, Sara
dc.contributor.author Hamdan, Firas
dc.contributor.author Chiaro, Jacopo
dc.contributor.author Ylösmäki, Leena
dc.contributor.author Vaughan, Matthew J.
dc.contributor.author Viitala, Tapani
dc.contributor.author Kulkarni, Prasad S.
dc.contributor.author Cerullo, Vincenzo
dc.date.accessioned 2021-09-20T11:03:01Z
dc.date.available 2021-09-20T11:03:01Z
dc.date.issued 2021
dc.identifier.citation Ylösmäki , E , Fusciello , M , Martins , B , Feola , S , Hamdan , F , Chiaro , J , Ylösmäki , L , Vaughan , M J , Viitala , T , Kulkarni , P S & Cerullo , V 2021 , ' Novel personalized cancer vaccine platform based on Bacillus Calmette-Guerin ' , Journal for Immunotherapy of Cancer , vol. 9 , no. 7 , 002707 . https://doi.org/10.1136/jitc-2021-002707
dc.identifier.other PURE: 168612987
dc.identifier.other PURE UUID: 3de12499-009d-40ad-b4ab-128276fd7f7c
dc.identifier.other WOS: 000691848000002
dc.identifier.other ORCID: /0000-0001-9074-9450/work/100257731
dc.identifier.uri http://hdl.handle.net/10138/334461
dc.description.abstract Background Intratumoral BCG therapy, one of the earliest immunotherapies, can lead to infiltration of immune cells into a treated tumor. However, an increase in the number of BCG-induced tumor-specific T cells in the tumor microenvironment could lead to enhanced therapeutic effects. Methods Here, we have developed a novel cancer vaccine platform based on BCG that can broaden BCG-induced immune responses to include tumor antigens. By physically attaching tumor-specific peptides onto the mycobacterial outer membrane, we were able to induce strong systemic and intratumoral T cell-specific immune responses toward the attached tumor antigens. These therapeutic peptides can be efficiently attached to the mycobacterial outer membrane using a poly-lysine sequence N-terminally fused to the tumor-specific peptides. Results Using two mouse models of melanoma and a mouse model of colorectal cancer, we observed that the antitumor immune responses of BCG could be improved by coating the BCG with tumor-specific peptides. In addition, by combining this novel cancer vaccine platform with anti-programmed death 1 (anti-PD-1) immune checkpoint inhibitor (ICI) therapy, the number of responders to anti-PD-1 immunotherapy was markedly increased. Conclusions This study shows that intratumoral BCG immunotherapy can be improved by coating the bacteria with modified tumor-specific peptides. In addition, this improved BCG immunotherapy can be combined with ICI therapy to obtain enhanced tumor growth control. These results warrant clinical testing of this novel cancer vaccine platform. en
dc.format.extent 13
dc.language.iso eng
dc.relation.ispartof Journal for Immunotherapy of Cancer
dc.rights cc_by
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject adaptive immunity
dc.subject immunity
dc.subject cellular
dc.subject immunogenicity
dc.subject vaccine
dc.subject immunotherapy
dc.subject active
dc.subject ADVANCED MELANOMA PATIENTS
dc.subject MYCOBACTERIUM-BOVIS BCG
dc.subject PRIME-BOOST VACCINATION
dc.subject TOPICAL IMIQUIMOD
dc.subject IMMUNE-RESPONSES
dc.subject SURFACE-CHARGE
dc.subject B16 MELANOMA
dc.subject TUMOR-GROWTH
dc.subject VIRUS
dc.subject IMMUNOTHERAPY
dc.subject 3122 Cancers
dc.subject 317 Pharmacy
dc.title Novel personalized cancer vaccine platform based on Bacillus Calmette-Guerin en
dc.type Article
dc.contributor.organization ImmunoViroTherapy Lab
dc.contributor.organization Division of Pharmaceutical Biosciences
dc.contributor.organization Drug Research Program
dc.contributor.organization TRIMM - Translational Immunology Research Program
dc.contributor.organization Division of Pharmaceutical Chemistry and Technology
dc.contributor.organization Pharmaceutical biophysics group
dc.contributor.organization Digital Precision Cancer Medicine (iCAN)
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1136/jitc-2021-002707
dc.relation.issn 2051-1426
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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