Sprayable antibacterial Persian gum-silver nanoparticle dressing for wound healing acceleration

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Amirsadeghi , A , Jafari , A , Hashemi , S-S , Kazemi , A , Ghasemi , Y , Derakhshanfar , A , Shahbazi , M-A & Niknezhad , S V 2021 , ' Sprayable antibacterial Persian gum-silver nanoparticle dressing for wound healing acceleration ' , Materials Today Communications , vol. 27 , 102225 . https://doi.org/10.1016/j.mtcomm.2021.102225

Title: Sprayable antibacterial Persian gum-silver nanoparticle dressing for wound healing acceleration
Author: Amirsadeghi, Armin; Jafari, Arman; Hashemi, Seyyedeh-Sara; Kazemi, Aboozar; Ghasemi, Younes; Derakhshanfar, Amin; Shahbazi, Mohammad-Ali; Niknezhad, Seyyed Vahid
Other contributor: University of Helsinki, Nanomedicines and Biomedical Engineering


Date: 2021-06
Language: eng
Number of pages: 10
Belongs to series: Materials Today Communications
ISSN: 2352-4928
DOI: https://doi.org/10.1016/j.mtcomm.2021.102225
URI: http://hdl.handle.net/10138/334464
Abstract: Wound infection is considered a significant challenge in skin injuries. Sprayable antibacterial wound dressings are interesting alternatives to their traditional counterparts because of their facile preparation, ease-of-use, and the possibility of topical delivery of antibacterial materials. Herein, novel sprayable antibacterial dressings are formulated and reported. The dressings were developed by in-situ formation of Ag-nanoparticles (Ag-NPs) using Persian gum (PG) as a carbohydrate polymer. Several tests were conducted to investigate the effect of polymer concentration on the sprayablity, biocompatibility, and antibacterial activity of the dressings (PG/Ag-NPs). Results showed that formulations up to 2 wt.% PG/Ag-NPs could be sprayed properly and form intact films. Antibacterial evaluations also showed biocidal activity of 1% PG/Ag-NPs against Pseudomonas aeruginosa and Staphylococcus aureus. Cytotoxicity and in vivo full-thickness wound healing evaluation confirmed that 1% PG/ Ag-NPs spray was safe and improved wound healing process. All the results confirmed the high potential of formulated sprayable dressings for wound repair.
Subject: Persian gum
Nanoparticle
Antibacterial
Spray
Skin
Wound dressing
NANOFIBERS
HYDROGELS
317 Pharmacy
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