Growth in Infants with Cow's Milk Protein Allergy Fed an Amino Acid-Based Formula

Show full item record



Permalink

http://hdl.handle.net/10138/334530

Citation

Mosaic Study Investigator Grp , Vandenplas , Y , Dupont , C , Eigenmann , P , Kuitunen , M & Zhao , Z-Y 2021 , ' Growth in Infants with Cow's Milk Protein Allergy Fed an Amino Acid-Based Formula ' , Pediatric gastroenterology hepatology & nutrition , vol. 24 , no. 4 , pp. 392-402 . https://doi.org/10.5223/pghn.2021.24.4.392

Title: Growth in Infants with Cow's Milk Protein Allergy Fed an Amino Acid-Based Formula
Author: Mosaic Study Investigator Grp; Vandenplas, Yvan; Dupont, Christophe; Eigenmann, Philippe; Kuitunen, Mikael; Zhao, Zheng-Yan
Contributor: University of Helsinki, Clinicum
Date: 2021-07
Language: eng
Number of pages: 11
Belongs to series: Pediatric gastroenterology hepatology & nutrition
ISSN: 2234-8646
URI: http://hdl.handle.net/10138/334530
Abstract: Purpose: The present study assessed the role of an amino acid-based formula (AAF) in the growth of infants with cow's milk protein allergy (CMPA). Methods: Non-breastfed, term infants aged 0-6 months with symptoms suggestive of CMPA were recruited from 10 pediatric centers in China. After enrollment, infants were started on AAF for two weeks, followed by an open food challenge (OFC) with cow's milk-based formula (CMF). Infants with confirmed CMPA remained on AAF until 9 months of age, in conjunction with a cow's milk protein-free complementary diet. Body weight, length, and head circumference were measured at enrollment and 9 months of age. Measurements were converted to weight-for-age, length-for-age, and head circumference-for-age Z scores (WAZ, LAZ, HCAZ), based on the World Health Organization growth reference. Results: Of 254 infants (median age 16.1 weeks, 50.9% male), 218 (85.8%) were diagnosed with non-IgE-mediated CMPA, 33 (13.0%) tolerated CMF, and 3 (1.2%) did not complete the OFC. The mean WAZ decreased from 0.119 to -0.029 between birth and enrollment (p=0.067), with significant catch-up growth to 0.178 at 9 months of age (p=0.012) while being fed the AAF. There were no significant changes in LAZ (0.400 vs. 0.552; p=0.214) or HCAZ (-0.356 vs. -0.284; p=0.705) from the time of enrollment to age 9 months, suggesting normal linear and head growth velocity. Conclusion: The amino acid-based study formula, in conjunction with a cow's milk protein-free complementary diet, supported normal growth till 9 months of age in a cohort of Chinese infants with challenge-confirmed non-IgE-mediated CMPA.
Subject: Anthropometry
Food hypersensitivity
Nutrition
Infant formula
Challenge test
FOOD ALLERGY
HYPOALLERGENICITY
CHILDREN
TOLERANCE
3123 Gynaecology and paediatrics
Rights:


Files in this item

Total number of downloads: Loading...

Files Size Format View
1121PGHN_pghn_24_392.pdf 1.741Mb PDF View/Open

This item appears in the following Collection(s)

Show full item record