Black box of phage-bacterium interactions : exploring alternative phage infection strategies

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Mäntynen , S , Laanto , E , Oksanen , H M , Poranen , M M & Diaz-Munoz , S L 2021 , ' Black box of phage-bacterium interactions : exploring alternative phage infection strategies ' , Open biology , vol. 11 , no. 9 , 210188 . https://doi.org/10.1098/rsob.210188

Title: Black box of phage-bacterium interactions : exploring alternative phage infection strategies
Author: Mäntynen, Sari; Laanto, Elina; Oksanen, Hanna M.; Poranen, Minna M.; Diaz-Munoz, Samuel L.
Other contributor: University of Helsinki, Molecular and Translational Virology
University of Helsinki, Molecular and Integrative Biosciences Research Programme
University of Helsinki, Molecular Principles of Viruses
University of Helsinki, Molecular and Integrative Biosciences Research Programme


Date: 2021-09-15
Language: eng
Number of pages: 12
Belongs to series: Open biology
ISSN: 2046-2441
DOI: https://doi.org/10.1098/rsob.210188
URI: http://hdl.handle.net/10138/334575
Abstract: The canonical lytic-lysogenic binary has been challenged in recent years, as more evidence has emerged on alternative bacteriophage infection strategies. These infection modes are little studied, and yet they appear to be more abundant and ubiquitous in nature than previously recognized, and can play a significant role in the ecology and evolution of their bacterial hosts. In this review, we discuss the extent, causes and consequences of alternative phage lifestyles, and clarify conceptual and terminological confusion to facilitate research progress. We propose distinct definitions for the terms 'pseudolysogeny' and 'productive or non-productive chronic infection', and distinguish them from the carrier state life cycle, which describes a population-level phenomenon. Our review also finds that phages may change their infection modes in response to environmental conditions or the physiological state of the host cell. We outline known molecular mechanisms underlying the alternative phage-host interactions, including specific genetic pathways and their considerable biotechnological potential. Moreover, we discuss potential implications of the alternative phage lifestyles for microbial biology and ecosystem functioning, as well as applied topics such as phage therapy.
Subject: bacteriophage
phage infection
pseudolysogeny
carrier state
chronic infection
BACTERIOPHAGE T7 DNA
FILAMENTOUS PHAGE
CARRIER STATE
PSEUDOMONAS-AERUGINOSA
HOST
VIRUS
INTEGRATION
PSEUDOLYSOGENY
CELLS
CONSTRUCTION
1182 Biochemistry, cell and molecular biology
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