Monitoring autophagy in cancer : From bench to bedside

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Long , M & McWilliams , T G 2020 , ' Monitoring autophagy in cancer : From bench to bedside ' , Seminars in Cancer Biology , vol. 66 , pp. 12-21 . https://doi.org/10.1016/j.semcancer.2019.05.016

Title: Monitoring autophagy in cancer : From bench to bedside
Author: Long, Maeve; McWilliams, Thomas G.
Other contributor: University of Helsinki, STEMM - Stem Cells and Metabolism Research Program
University of Helsinki, Department of Anatomy




Date: 2020-11
Language: eng
Number of pages: 10
Belongs to series: Seminars in Cancer Biology
ISSN: 1044-579X
DOI: https://doi.org/10.1016/j.semcancer.2019.05.016
URI: http://hdl.handle.net/10138/334596
Abstract: Autophagy refers to an essential mechanism that evolved to sustain eukaryotic homeostasis and metabolism during instances of nutrient deprivation. During autophagy, intracellular cargo is encapsulated and delivered to the lysosome for elimination. Loss of basal autophagy in vivo negatively impacts cellular proteostasis, metabolism and tissue integrity. Accordingly, many drug development strategies are focused on modulating autophagic capacity in various pathophysiological states, from cancer to neurodegenerative disease. The role of autophagy in cancer is particularly complicated, as either augmenting or attenuating this process can have variable outcomes on cellular survival, proliferation and transformation. This complexity is compounded by the emergence of several selective autophagy pathways, which act to eliminate damaged or superfluous cellular components in a targeted fashion. The advent of sensitive tools to monitor autophagy pathways in vivo holds promise to clarify their importance in cancer pathophysiology. In this review, we provide an overview of autophagy in cancer biology and outline how the development of tools to study autophagy in vivo could enhance our understanding of its function for translational benefit.
Subject: Autophagy
Autophagosome
Cancer
Metabolism
Mitochondria
Mitophagy
mito-QC
Tumour
Organelles
CALORIC RESTRICTION MIMETICS
PANCREATIC-CANCER
TUMOR-GROWTH
MITOPHAGY
MITOCHONDRIAL
LYSOSOME
PARKIN
DETERMINES
PROMOTES
P53
3122 Cancers
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