Dendritic Spine Initiation in Brain Development, Learning and Diseases and Impact of BAR-Domain Proteins

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dc.contributor.author Khanal, Pushpa
dc.contributor.author Hotulainen, Pirta
dc.date.accessioned 2021-09-25T23:33:18Z
dc.date.available 2021-09-25T23:33:18Z
dc.date.issued 2021-09-12
dc.identifier.citation Khanal, P.; Hotulainen, P. Dendritic Spine Initiation in Brain Development, Learning and Diseases and Impact of BAR-Domain Proteins. Cells 2021, 10, 2392.
dc.identifier.uri http://hdl.handle.net/10138/334601
dc.description.abstract Dendritic spines are small, bulbous protrusions along neuronal dendrites where most of the excitatory synapses are located. Dendritic spine density in normal human brain increases rapidly before and after birth achieving the highest density around 2–8 years. Density decreases during adolescence, reaching a stable level in adulthood. The changes in dendritic spines are considered structural correlates for synaptic plasticity as well as the basis of experience-dependent remodeling of neuronal circuits. Alterations in spine density correspond to aberrant brain function observed in various neurodevelopmental and neuropsychiatric disorders. Dendritic spine initiation affects spine density. In this review, we discuss the importance of spine initiation in brain development, learning, and potential complications resulting from altered spine initiation in neurological diseases. Current literature shows that two Bin Amphiphysin Rvs (BAR) domain-containing proteins, MIM/Mtss1 and SrGAP3, are involved in spine initiation. We review existing literature and open databases to discuss whether other BAR-domain proteins could also take part in spine initiation. Finally, we discuss the potential molecular mechanisms on how BAR-domain proteins could regulate spine initiation.
dc.publisher Multidisciplinary Digital Publishing Institute
dc.title Dendritic Spine Initiation in Brain Development, Learning and Diseases and Impact of BAR-Domain Proteins
dc.date.updated 2021-09-25T23:33:18Z
dc.type.uri http://purl.org/eprint/entityType/JournalArticle
dc.type.uri http://purl.org/eprint/entityType/Expression
dc.type.uri http://purl.org/eprint/entityType/Expression

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