Räty , S , Borrmann , C , Granata , G , Cardenas-Morales , L , Schoenfeld , A , Sailer , M , Silvennoinen , K , Holopainen , J , De Rossi , F , Antal , A , Rossini , P M , Tatlisumak , T & Sabel , B A 2021 , ' Non-invasive electrical brain stimulation for vision restoration after stroke : An exploratory randomized trial (REVIS) ' , Restorative Neurology and Neuroscience , vol. 39 , no. 3 , pp. 221-235 . https://doi.org/10.3233/RNN-211198
Titel: | Non-invasive electrical brain stimulation for vision restoration after stroke : An exploratory randomized trial (REVIS) |
Författare: | Räty, Silja; Borrmann, Carolin; Granata, Giuseppe; Cardenas-Morales, Lizbeth; Schoenfeld, Ariel; Sailer, Michael; Silvennoinen, Katri; Holopainen, Juha; De Rossi, Francesca; Antal, Andrea; Rossini, Paolo M.; Tatlisumak, Turgut; Sabel, Bernhard A. |
Upphovmannens organisation: | HUS Neurocenter Neurologian yksikkö University of Helsinki HUS Head and Neck Center Department of Ophthalmology and Otorhinolaryngology Silmäklinikka |
Datum: | 2021 |
Språk: | eng |
Sidantal: | 15 |
Tillhör serie: | Restorative Neurology and Neuroscience |
ISSN: | 0922-6028 |
DOI: | https://doi.org/10.3233/RNN-211198 |
Permanenta länken (URI): | http://hdl.handle.net/10138/334644 |
Abstrakt: | Background: Occipital strokes often cause permanent homonymous hemianopia leading to significant disability. In previous studies, non-invasive electrical brain stimulation (NIBS) has improved vision after optic nerve damage and in combination with training after stroke. Objective: We explored different NIBS modalities for rehabilitation of hemianopia after chronic stroke. Methods: In a randomized, double-blinded, sham-controlled, three-armed trial, altogether 56 patients with homonymous hemianopia were recruited. The three experiments were: i) repetitive transorbital alternating current stimulation (rtACS, n=8) vs. rtACS with prior cathodal transcranial direct current stimulation over the intact visual cortex (tDCS/rtACS, n=8) vs. sham (n = 8); ii) rtACS (n = 9) vs. sham (n = 9); and iii) tDCS of the visual cortex (n = 7) vs. sham (n = 7). Visual functions were evaluated before and after the intervention, and after eight weeks follow-up. The primary outcome was change in visual field assessed by high-resolution and standard perimetries. The individual modalities were compared within each experimental arm. Results: Primary outcomes in Experiments 1 and 2 were negative. Only significant between-group change was observed in Experiment 3, where tDCS increased visual field of the contralesional eye compared to sham. tDCS/rtACS improved dynamic vision, reading, and visual field of the contralesional eye, but was not superior to other groups. rtACS alone increased foveal sensitivity, but was otherwise ineffective. All trial-related procedures were tolerated well. Conclusions: This exploratory trial showed safety but no main effect of NIBS on vision restoration after stroke. However, tDCS and combined tDCS/rtACS induced improvements in visually guided performance that need to be confirmed in larger-sample trials. |
Subject: |
Electrical stimulation
homonymous hemianopia randomized controlled trial rehabilitation occipital stroke vision restoration ALTERNATING-CURRENT STIMULATION VISUAL FUNCTION HEMIANOPIA RECOVERY FIELD SENSITIVITY PLASTICITY 3112 Neurosciences 3124 Neurology and psychiatry |
Referentgranskad: | Ja |
Licens: | cc_by_nc |
Användningsbegränsning: | openAccess |
Parallelpublicerad version: | publishedVersion |
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