Non-invasive electrical brain stimulation for vision restoration after stroke : An exploratory randomized trial (REVIS)

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dc.contributor.author Räty, Silja
dc.contributor.author Borrmann, Carolin
dc.contributor.author Granata, Giuseppe
dc.contributor.author Cardenas-Morales, Lizbeth
dc.contributor.author Schoenfeld, Ariel
dc.contributor.author Sailer, Michael
dc.contributor.author Silvennoinen, Katri
dc.contributor.author Holopainen, Juha
dc.contributor.author De Rossi, Francesca
dc.contributor.author Antal, Andrea
dc.contributor.author Rossini, Paolo M.
dc.contributor.author Tatlisumak, Turgut
dc.contributor.author Sabel, Bernhard A.
dc.date.accessioned 2021-09-28T05:40:04Z
dc.date.available 2021-09-28T05:40:04Z
dc.date.issued 2021
dc.identifier.citation Räty , S , Borrmann , C , Granata , G , Cardenas-Morales , L , Schoenfeld , A , Sailer , M , Silvennoinen , K , Holopainen , J , De Rossi , F , Antal , A , Rossini , P M , Tatlisumak , T & Sabel , B A 2021 , ' Non-invasive electrical brain stimulation for vision restoration after stroke : An exploratory randomized trial (REVIS) ' , Restorative Neurology and Neuroscience , vol. 39 , no. 3 , pp. 221-235 . https://doi.org/10.3233/RNN-211198
dc.identifier.other PURE: 168812490
dc.identifier.other PURE UUID: cc31663e-1792-4982-9370-c5f64150bdd9
dc.identifier.other WOS: 000683028500006
dc.identifier.uri http://hdl.handle.net/10138/334644
dc.description.abstract Background: Occipital strokes often cause permanent homonymous hemianopia leading to significant disability. In previous studies, non-invasive electrical brain stimulation (NIBS) has improved vision after optic nerve damage and in combination with training after stroke. Objective: We explored different NIBS modalities for rehabilitation of hemianopia after chronic stroke. Methods: In a randomized, double-blinded, sham-controlled, three-armed trial, altogether 56 patients with homonymous hemianopia were recruited. The three experiments were: i) repetitive transorbital alternating current stimulation (rtACS, n=8) vs. rtACS with prior cathodal transcranial direct current stimulation over the intact visual cortex (tDCS/rtACS, n=8) vs. sham (n = 8); ii) rtACS (n = 9) vs. sham (n = 9); and iii) tDCS of the visual cortex (n = 7) vs. sham (n = 7). Visual functions were evaluated before and after the intervention, and after eight weeks follow-up. The primary outcome was change in visual field assessed by high-resolution and standard perimetries. The individual modalities were compared within each experimental arm. Results: Primary outcomes in Experiments 1 and 2 were negative. Only significant between-group change was observed in Experiment 3, where tDCS increased visual field of the contralesional eye compared to sham. tDCS/rtACS improved dynamic vision, reading, and visual field of the contralesional eye, but was not superior to other groups. rtACS alone increased foveal sensitivity, but was otherwise ineffective. All trial-related procedures were tolerated well. Conclusions: This exploratory trial showed safety but no main effect of NIBS on vision restoration after stroke. However, tDCS and combined tDCS/rtACS induced improvements in visually guided performance that need to be confirmed in larger-sample trials. en
dc.format.extent 15
dc.language.iso eng
dc.relation.ispartof Restorative Neurology and Neuroscience
dc.rights cc_by_nc
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject Electrical stimulation
dc.subject homonymous hemianopia
dc.subject randomized controlled trial
dc.subject rehabilitation
dc.subject occipital stroke
dc.subject vision restoration
dc.subject ALTERNATING-CURRENT STIMULATION
dc.subject VISUAL FUNCTION
dc.subject HEMIANOPIA
dc.subject RECOVERY
dc.subject FIELD
dc.subject SENSITIVITY
dc.subject PLASTICITY
dc.subject 3112 Neurosciences
dc.subject 3124 Neurology and psychiatry
dc.title Non-invasive electrical brain stimulation for vision restoration after stroke : An exploratory randomized trial (REVIS) en
dc.type Article
dc.contributor.organization HUS Neurocenter
dc.contributor.organization Neurologian yksikkö
dc.contributor.organization University of Helsinki
dc.contributor.organization HUS Head and Neck Center
dc.contributor.organization Department of Ophthalmology and Otorhinolaryngology
dc.contributor.organization Silmäklinikka
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.3233/RNN-211198
dc.relation.issn 0922-6028
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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