Measuring routine childhood vaccination coverage in 204 countries and territories, 1980-2019 : a systematic analysis for the Global Burden of Disease Study 2020, Release 1

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dc.contributor.author GBD 2020 Release 1 Vaccine Coverag
dc.contributor.author Galles, Natalie C.
dc.contributor.author Liu, Patrick Y.
dc.contributor.author Updike, Rachel L.
dc.contributor.author Meretoja, Tuomo J.
dc.date.accessioned 2021-09-28T05:59:02Z
dc.date.available 2021-09-28T05:59:02Z
dc.date.issued 2021-08-07
dc.identifier.citation GBD 2020 Release 1 Vaccine Coverag , Galles , N C , Liu , P Y , Updike , R L & Meretoja , T J 2021 , ' Measuring routine childhood vaccination coverage in 204 countries and territories, 1980-2019 : a systematic analysis for the Global Burden of Disease Study 2020, Release 1 ' , Lancet , vol. 398 , no. 10299 , pp. 503-521 . https://doi.org/10.1016/S0140-6736(21)00984-3
dc.identifier.other PURE: 168813460
dc.identifier.other PURE UUID: 244d3f16-91a6-4fe8-8f2a-b7f0eb2aabeb
dc.identifier.other WOS: 000681776000024
dc.identifier.other ORCID: /0000-0002-2691-0710/work/100696419
dc.identifier.uri http://hdl.handle.net/10138/334646
dc.description.abstract Background Measuring routine childhood vaccination is crucial to inform global vaccine policies and programme implementation, and to track progress towards targets set by the Global Vaccine Action Plan (GVAP) and Immunization Agenda 2030. Robust estimates of routine vaccine coverage are needed to identify past successes and persistent vulnerabilities. Drawing from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2020, Release 1, we did a systematic analysis of global, regional, and national vaccine coverage trends using a statistical framework, by vaccine and over time. Methods For this analysis we collated 55 326 country-specific, cohort-specific, year-specific, vaccine-specific, and dosespecific observations of routine childhood vaccination coverage between 1980 and 2019. Using spatiotemporal Gaussian process regression, we produced location-specific and year-specific estimates of 11 routine childhood vaccine coverage indicators for 204 countries and territories from 1980 to 2019, adjusting for biases in countryreported data and reflecting reported stockouts and supply disruptions. We analysed global and regional trends in coverage and numbers of zero-dose children (defined as those who never received a diphtheria-tetanus-pertussis [DTP] vaccine dose), progress towards GVAP targets, and the relationship between vaccine coverage and sociodemographic development. Findings By 2019, global coverage of third-dose DTP (DTP3; 81.6% [95% uncertainty interval 80.4-82 .7]) more than doubled from levels estimated in 1980 (39.9% [37.5-42.1]), as did global coverage of the first-dose measles-containing vaccine (MCV1; from 38.5% [35.4-41.3] in 1980 to 83.6% [82.3-84.8] in 2019). Third- dose polio vaccine (Pol3) coverage also increased, from 42.6% (41.4-44.1) in 1980 to 79.8% (78.4-81.1) in 2019, and global coverage of newer vaccines increased rapidly between 2000 and 2019. The global number of zero-dose children fell by nearly 75% between 1980 and 2019, from 56.8 million (52.6-60. 9) to 14.5 million (13.4-15.9). However, over the past decade, global vaccine coverage broadly plateaued; 94 countries and territories recorded decreasing DTP3 coverage since 2010. Only 11 countries and territories were estimated to have reached the national GVAP target of at least 90% coverage for all assessed vaccines in 2019. Interpretation After achieving large gains in childhood vaccine coverage worldwide, in much of the world this progress was stalled or reversed from 2010 to 2019. These findings underscore the importance of revisiting routine immunisation strategies and programmatic approaches, recentring service delivery around equity and underserved populations. Strengthening vaccine data and monitoring systems is crucial to these pursuits, now and through to 2030, to ensure that all children have access to, and can benefit from, lifesaving vaccines. Copyright (C) 2021 The Author(s). Published by Elsevier Ltd. en
dc.format.extent 19
dc.language.iso eng
dc.relation.ispartof Lancet
dc.rights cc_by
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject IMMUNIZATION COVERAGE
dc.subject IMPACT
dc.subject MORTALITY
dc.subject WORLDWIDE
dc.subject CONFLICT
dc.subject VALIDITY
dc.subject PROGRESS
dc.subject 3121 General medicine, internal medicine and other clinical medicine
dc.title Measuring routine childhood vaccination coverage in 204 countries and territories, 1980-2019 : a systematic analysis for the Global Burden of Disease Study 2020, Release 1 en
dc.type Article
dc.contributor.organization HUS Comprehensive Cancer Center
dc.contributor.organization University of Helsinki
dc.contributor.organization Helsinki University Hospital Area
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1016/S0140-6736(21)00984-3
dc.relation.issn 0140-6736
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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