Microfluidic analysis techniques for safety assessment of pharmaceutical nano- and microsystems

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Sikanen , T , Kiiski , I & Ollikainen , E 2021 , Microfluidic analysis techniques for safety assessment of pharmaceutical nano- and microsystems . in L Peltonen (ed.) , Characterization of Pharmaceutical Nano- and Microsystems . Advances in Pharmaceutical Technology , John Wiley & Sons Ltd. , Hoboken , pp. 97-135 . https://doi.org/10.1002/9781119414018.ch3

Title: Microfluidic analysis techniques for safety assessment of pharmaceutical nano- and microsystems
Author: Sikanen, Tiina; Kiiski, Iiro; Ollikainen, Elisa
Other contributor: University of Helsinki, Drug Research Program
University of Helsinki, Division of Pharmaceutical Chemistry and Technology
University of Helsinki, Tiina Sikanen / Chemical Microsystems Lab
Peltonen, Leena


Publisher: John Wiley & Sons Ltd.
Date: 2021-01-19
Language: eng
Number of pages: 38
Belongs to series: Characterization of Pharmaceutical Nano- and Microsystems
Belongs to series: Advances in Pharmaceutical Technology
ISBN: 9781119414049
9781119414018
DOI: https://doi.org/10.1002/9781119414018.ch3
URI: http://hdl.handle.net/10138/334794
Abstract: This chapter reviews the evolution of microfabrication methods and materials, applicable to manufacturing of micro total analysis systems (or lab‐on‐a‐chip), from a general perspective. It discusses the possibilities and limitations associated with microfluidic cell culturing, or so called organ‐on‐a‐chip technology, together with selected examples of their exploitation to characterization of pharmaceutical nano‐ and microsystems. Materials selection plays a pivotal role in terms of ensuring the cell adhesion and viability as well as defining the prevailing culture conditions inside the microfluidic channels. The chapter focuses on the hepatic safety assessment of nanoparticles and gives an overview of the development of microfluidic immobilized enzyme reactors that could facilitate examination of the hepatic effects of nanomedicines under physiologically relevant conditions. It also provides an overview of the future prospects regarding system‐level integration possibilities facilitated by microfabrication of miniaturized separation and sample preparation systems as integral parts of microfluidic in vitro models.
Subject: 116 Chemical sciences
221 Nano-technology
microfluidics
microfabrication
organ-on-a-ship
immobilized enzyme reactors
microship electrophoresis
drug metabolism
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