Serum Inhibin-A and PAPP-A2 in the prediction of pre-eclampsia during the first and second trimesters in high-risk women

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Keikkala , E , Forsten , J , Ritvos , O , Stenman , U-H , Kajantie , E , Hämäläinen , E , Räikkönen , K , Villa , P M & Laivuori , H 2021 , ' Serum Inhibin-A and PAPP-A2 in the prediction of pre-eclampsia during the first and second trimesters in high-risk women ' , Pregnancy Hypertension : an international journal of women's cardiovascular health , vol. 25 , pp. 116-122 . https://doi.org/10.1016/j.preghy.2021.05.024

Title: Serum Inhibin-A and PAPP-A2 in the prediction of pre-eclampsia during the first and second trimesters in high-risk women
Author: Keikkala, Elina; Forsten, Janina; Ritvos, Olli; Stenman, Ulf-Håkan; Kajantie, Eero; Hämäläinen, Esa; Räikkönen, Katri; Villa, Pia M.; Laivuori, Hannele
Contributor organization: Lastenpsykiatria
HUS Children and Adolescents
Department of Physiology
Growth factor physiology
Department of Bacteriology and Immunology
Department of Clinical Chemistry and Hematology
Department of Diagnostics and Therapeutics
Lastentautien yksikkö
Children's Hospital
Clinicum
Medicum
HUSLAB
Department of Psychology and Logopedics
HUS Gynecology and Obstetrics
Hyvinkää Hospital Area
Genomics of Neurological and Neuropsychiatric Disorders
Institute for Molecular Medicine Finland
Pregnancy and Genes
Department of Medical and Clinical Genetics
Doctoral Programme in Human Behaviour
Date: 2021-08
Language: eng
Number of pages: 7
Belongs to series: Pregnancy Hypertension : an international journal of women's cardiovascular health
ISSN: 2210-7789
DOI: https://doi.org/10.1016/j.preghy.2021.05.024
URI: http://hdl.handle.net/10138/334845
Abstract: Objectives: Maternal serum inhibin-A , pregnancy associated plasma protein-A (PAPP-A) and PAPP-A2 together with placental growth factor (PlGF), maternal risk factors and uterine arter y pulsatility inde x (UtA PI) were analysed to study thei r ability to predict pre-eclampsia (PE). Study design: Serial serum samples for the nested case-control study were collected prospectively at 12-14, 18-20 and 26-28 weeks of gestation from 11 women who later developed early-onset PE (EO PE , diagnosis < 34 + 0 weeks of gestation), 34 women who developed late-onset PE (LO PE , diagnosis 2 34 + 0 weeks) and 89 controls. Main outcome measures: Gestational age-adjusted multiples of the median (MoM) values were calculated for biomarker concentrations. Multivariate regression analyses were performed to combine first trimester bio-markers, previously reported results on PlGF, maternal risk factors and UtA PI. Area under cu r v e (AUC) values and 95% confidence intervals (CIs) for the prediction of PE and its subtypes were calculated . Results: A high first trimester inhibin-A predicted PE (AUC 0.618, 95%CI, 0.513-0.724), whereas PAPP-A and PlGF predicted only EO PE (0.701, 0.562-0.840 and 0.798, 0.686-0.909, respectively). At 26-28 weeks PAPP-A2 and inhibin-A predicted a l l PE subtypes. In the multivariate setting inhibin-A combined with maternal pre-pregnancy body mass index, prior PE and mean UtA PI predicted PE (0.811,0.726-0.896) and LO PE (0.824, 0.733-0.914). Conclusions: At first trimester inhibin-A show potential ability to predict not only EO PE but also LO PE whereas PlGF and PAPP-A predict only EO PE. At late second trimester inhibin-A and PAPP-A2 might be usef u l for short-term prediction of PE.
Subject: Pre-eclampsia
Prediction
Pregnancy
inhibin-A
pregnancy associated plasm a protein-A2
Placental growth factor
PLASMA-PROTEIN-A
LOW-DOSE ASPIRIN
EARLY-PREGNANCY
ACTIVIN-A
EXPRESSION
GESTATION
MARKERS
LOCALIZATION
ACID
3123 Gynaecology and paediatrics
3121 General medicine, internal medicine and other clinical medicine
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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