Modeling drug combination effects via latent tensor reconstruction

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Wang , T , Szedmak , S , Wang , H , Aittokallio , T , Pahikkala , T , Cichonska , A & Rousu , J 2021 , ' Modeling drug combination effects via latent tensor reconstruction ' , Bioinformatics , vol. 37 , pp. I93-I101 .

Title: Modeling drug combination effects via latent tensor reconstruction
Author: Wang, Tianduanyi; Szedmak, Sandor; Wang, Haishan; Aittokallio, Tero; Pahikkala, Tapio; Cichonska, Anna; Rousu, Juho
Contributor organization: Institute for Molecular Medicine Finland
Computational Systems Medicine
Department of Computer Science
Helsinki Institute for Information Technology
Tero Aittokallio / Principal Investigator
Date: 2021-07
Language: eng
Number of pages: 9
Belongs to series: Bioinformatics
ISSN: 1367-4803
Abstract: Motivation: Combination therapies have emerged as a powerful treatment modality to overcome drug resistance and improve treatment efficacy. However, the number of possible drug combinations increases very rapidly with the number of individual drugs in consideration, which makes the comprehensive experimental screening infeasible in practice. Machine-learning models offer time- and cost-efficient means to aid this process by prioritizing the most effective drug combinations for further pre-clinical and clinical validation. However, the complexity of the underlying interaction patterns across multiple drug doses and in different cellular contexts poses challenges to the predictive modeling of drug combination effects. Results: We introduce comboLTR, highly time-efficient method for learning complex, non-linear target functions for describing the responses of therapeutic agent combinations in various doses and cancer cell-contexts. The method is based on a polynomial regression via powerful latent tensor reconstruction. It uses a combination of recommender system-style features indexing the data tensor of response values in different contexts, and chemical and multi-omics features as inputs. We demonstrate that comboLTR outperforms state-of-the-art methods in terms of predictive performance and running time, and produces highly accurate results even in the challenging and practical inference scenario where full dose-response matrices are predicted for completely new drug combinations with no available combination and monotherapy response measurements in any training cell line.
Subject: CANCER
3122 Cancers
113 Computer and information sciences
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion

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