Dual-Crosslinked Dynamic Hydrogel Incorporating {Mo-154} with pH and NIR Responsiveness for Chemo-Photothermal Therapy

Show full item record




Guedes , G , Wang , S , Fontana , F , Figueiredo , P , Linden , J , Correia , A , Pinto , R J B , Hietala , S , Sousa , F L & Santos , H A 2021 , ' Dual-Crosslinked Dynamic Hydrogel Incorporating {Mo-154} with pH and NIR Responsiveness for Chemo-Photothermal Therapy ' , Advanced Materials , vol. 33 , no. 40 , 2007761 . https://doi.org/10.1002/adma.202007761

Title: Dual-Crosslinked Dynamic Hydrogel Incorporating {Mo-154} with pH and NIR Responsiveness for Chemo-Photothermal Therapy
Author: Guedes, Gabriela; Wang, Shiqi; Fontana, Flavia; Figueiredo, Patricia; Linden, Jere; Correia, Alexandra; Pinto, Ricardo J. B.; Hietala, Sami; Sousa, Filipa L.; Santos, Helder A.
Contributor organization: Faculty of Pharmacy
Drug Research Program
Division of Pharmaceutical Chemistry and Technology
Nanomedicines and Biomedical Engineering
Veterinary Pathology and Parasitology
Department of Chemistry
Helsinki One Health (HOH)
Divisions of Faculty of Pharmacy
Helsinki Institute of Life Science HiLIFE
Date: 2021-10-07
Language: eng
Number of pages: 10
Belongs to series: Advanced Materials
ISSN: 0935-9648
DOI: https://doi.org/10.1002/adma.202007761
URI: http://hdl.handle.net/10138/335079
Abstract: Polyoxometalates are an emerging class of molecular clusters, with well-defined structures and chemical compositions that are produced through simple, low-cost, and highly reproducible methods. In particular, the wheel-shaped cluster {Mo154} is a promising photothermal agent due to its intervalence charge transfer transitions. However, its toxicity hinders its systemic administration, being the development of a localized delivery system still incipient. Herein, an injectable and self-healing hydrogel of easy preparation and administration is developed, incorporating both {Mo154} and doxorubicin for synergistic photothermal and chemotherapy applications. The hydrogel is composed of benzylaldehyde functionalized polyethylene glycol, poly(N-isopropylacrylamide) functionalized chitosan and {Mo154}. The gelation occurs within 60 s at room temperature, and the dual crosslinking by Schiff base and electrostatic interactions generates a dynamic network, which enables self-healing after injection. Moreover, the hydrogel delivers chemotherapeutic drugs, with a release triggered by dual near infra-red (NIR) radiation and pH changes. This stimuli-responsive release system along with the photothermal conversion ability of the hydrogel allows the simultaneous combination of photothermal and chemotherapy. This synergic system efficiently ablates the cancer tumor in vivo with no systemic toxicity. Overall, this work paves the way for the development of novel {Mo154}-based systems, incorporated in self-healing and injectable hydrogels for dual chemo-photothermal therapy.
Subject: {Mo
chemo-photothermal therapy
injectable hydrogel
1182 Biochemistry, cell and molecular biology
Peer reviewed: Yes
Rights: cc_by_nc_nd
Usage restriction: openAccess
Self-archived version: acceptedVersion

Files in this item

Total number of downloads: Loading...

Files Size Format View
Manuscript_SI_Revised_2021_05_04.docx 13.98Mb Microsoft Word View/Open

This item appears in the following Collection(s)

Show full item record