Effect of a Multidomain Lifestyle Intervention on Estimated Dementia Risk

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Solomon , A , Handels , R , Wimo , A , Antikainen , R , Laatikainen , T , Levälahti , E , Peltonen , M , Soininen , H , Strandberg , T , Tuomilehto , J , Kivipelto , M & Ngandu , T 2021 , ' Effect of a Multidomain Lifestyle Intervention on Estimated Dementia Risk ' , Journal of Alzheimer's Disease , vol. 82 , no. 4 , pp. 1461-1466 . https://doi.org/10.3233/JAD-210331

Title: Effect of a Multidomain Lifestyle Intervention on Estimated Dementia Risk
Author: Solomon, Alina; Handels, Ron; Wimo, Anders; Antikainen, Riitta; Laatikainen, Tiina; Levälahti, Esko; Peltonen, Markku; Soininen, Hilkka; Strandberg, Timo; Tuomilehto, Jaakko; Kivipelto, Miia; Ngandu, Tiia
Contributor: University of Helsinki, HUS Internal Medicine and Rehabilitation
University of Helsinki, Clinicum
Date: 2021
Language: eng
Number of pages: 6
Belongs to series: Journal of Alzheimer's Disease
ISSN: 1387-2877
URI: http://hdl.handle.net/10138/335116
Abstract: We investigated the effect of a multidomain lifestyle intervention on the risk of dementia estimated using the validated CAIDE risk score (post-hoc analysis). The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) is a 2-year randomized controlled trial among 1,260 at-risk older adults (60-77 years). Difference in the estimated mean change in CAIDE score at 2 years in the intervention compared to the control group was -0.16 (95 % CI -0.31 to 0.00) (p = 0.013), corresponding to a relative dementia risk reduction between 6.04-6.50%. This could be interpreted as a reflection of the prevention potential of the intervention.
Subject: Clinical trial
dementia
dementia risk score
lifestyle intervention
prevention
FINNISH GERIATRIC INTERVENTION
PREVENT COGNITIVE IMPAIRMENT
ALZHEIMERS-DISEASE
PREDICTION
FINGER
TRIALS
SCORE
3112 Neurosciences
3124 Neurology and psychiatry
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